LNA Tools for RNA and miRNA Functional Analysis

miRNA function.
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Highly effective mRNA and lncRNA silencing in vitro and in vivo
Antisense LNA GapmeRs are potent antisense oligonucleotides that provide highly efficient knockdown of mRNA and lncRNA in vitro and in vivo. Our Antisense LNA GapmeR design tool evaluates thousands of possible designs against >30 different parameters to identify the optimal design for potent and specific knockdown of your target. Use the design tool to ensure excellent performance and high success rates. Access the Antisense LNA GapmeR design tool in GeneGlobe to design and order your own GapmeRs.

Long-lasting and powerful miRNA inhibition in vitro and in vivo
miRCURY LNA miRNA Inhibitors and Power Inhibitors are LNA-enhanced, antisense miRNA inhibitors that allow you to assess cellular phenotypes in miRNA loss-of-function studies. LNA enhancement provides high potency, minimal off-target effects and long-lasting inhibition, even in difficult-to-transfect cell lines and animal models. For functional analysis of an entire miRNA family, select the Family Power Inhibitors. Or for genomewide, high-throughput screening of miRNA function, choose the miRNA Inhibitor Libraries. LNA enhancement and Tm normalization ensure highly efficient targeting, regardless of GC content.

Highly potent, mature miRNA mimicry for gain-of-function studies
miRCURY LNA miRNA Mimics are highly potent, mature miRNA mimics that simulate naturally occurring mature miRNAs. Their innovative design includes two short, LNA-enhanced complimentary strands that prevent any miRNA-like activity associated with the passenger strands. This ensures that the observed phenotypes result from increased activity of the mimicked miRNA.

​High-efficacy and specific inhibition of miRNA targets in vitro and in vivo
miRCURY LNA miRNA Power Target Site Blockers are antisense oligos that bind to the miRNA target site of an mRNA, preventing miRNAs from gaining access to that site. This allows you to study the effects of an individual miRNA on a single target site. The LNA-enhanced design provides high affinity and efficiency at low concentrations, for stable and long-lasting antisense activity.

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For miRNA loss-of-function studies using LNA-enhanced antisense miRNA inhibitors
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For analyzing regulatory roles shared by highly related, co-expressed and functionally redundant miRNAs
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For genomewide, high-throughput screening of miRNA function using LNA-enhanced miRNA inhibitors
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For studies on miRNA function and gene regulation using synthetic miRNA
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For studying the effects of an individual miRNA on a single target site
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For miRNA function studies using LNA-enhanced antisense miRNA inhibitors
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For highly effective knockdown of mRNA and lncRNA using LNA-enhanced antisense oligonucleotides
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For RNA functional analysis screening projects using custom 96-well plates of Antisense LNA GapmeRs
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