Reveal epigenetic mechanisms in difficult samples
Genetic alterations do not represent the full picture of gene expression or cellular function changes that are observable during oncogenesis. Epigenetic mechanisms influence gene activity without changing the DNA sequence and include DNA methylation, which is associated with gene silencing of tumor suppressor or DNA repair genes. DNA methylation is a stable, heritable, covalent modification to DNA, occurring mainly at CpG dinucleotides, but is also found at non-CpG sites. Interrogating DNA methylation degree can be challenging in FFPE and liquid biopsy samples, amplifying the need for robust, reliable solutions that work with low-input samples. QIAGEN’s Sample to Insight solutions for epigenetics applications address these challenges to deliver reliable data and powerful insights.
What’s new in the world of epigenetics?
Hypomethylation vs. hypermethylation
Watch the latest webinars on methylation analysis
Unlock liquid biopsy samples with NGS-based methylation detection from 10 ng DNAIn this new webinar, we introduce a novel, highly sensitive and faster NGS-based approach to targeted methylation detection using the QIAseq Targeted and Custom Methyl Panels.
Streamlining analysis of targeted NGS methylation data using QIAGEN CLC Genomics Workbench softwareIn this webinar, we describe additional aspects of our Sample to Insight solution, focusing on the analysis and visualization of targeted methyl panel data using QIAGEN CLC Genomics Workbench software.