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Antisense LNA GapmeRs

Antisense LNA GapmeRs are highly potent, single-stranded antisense oligonucleotides (ASO) for silencing of lncRNA and mRNA in cell cultures and in animal models. The GapmeRs are enhanced with LNA technology and are designed using sophisticated and empirically developed algorithms and offer excellent performance and high success rates.

  • Function by RNase H-dependent degradation of complementary RNA targets
  • Provide strand-specific knockdown with no RISC-associated off-target activity
  • Active in vivo and in vitro, enabling the analysis RNA function in a wide range of model systems
  • Excellent alternative to siRNA for knockdown of mRNA and lncRNA
  • Taken up by cells without need for transfection reagents
  • Variety of controls support transfection or unassisted uptake protocol optimization
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