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Cignal Reporter Assay Kits

For rapid, sensitive, and quantitative assessment of signal transduction pathway activation

  • Rapid analysis of signal transduction pathway regulation
  • Exceptional sensitivity and specificity
  • Transfection-ready constructs
  • Includes positive and negative controls
  • Real-time live cell quantification (GFP format)

Cignal Reporter Assays provided in the Cignal Reporter Assay Kit enable rapid, sensitive, and quantitative assessment of signal transduction pathway activation by measuring the activities of downstream transcription factors. Two reporter systems are available: dual-luciferase format and GFP format.

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Cignal Reporter Assay Kits are intended for molecular biology applications. These products are not intended for the diagnosis, prevention, or treatment of a disease.


0
TNFα activates NFkB signaling activity in a dose-dependent manner.
293 H cells were transfected with Cignal NFkB Reporter Assay, negative or positive control. After 24 hours, cells were treated with different doses of hTNFα for a further 24 hours. Dual-luciferase assays were performed, and reporter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate and standard deviation is shown.
1
Assessing RNA interference phenotypes.

Cignal p53 Reporter Assays showed that p53 siRNA treatment abolished p53 transcription activity. HCT 116 cells were transfected with p53 reporter, negative control, and positive control, together with p53 siRNA or negative control siRNA. Dual-luciferase assays were performed. Reporter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate and the standard deviation is shown.

2
Assessing overexpression phenotypes.

Cignal RBP-Jκ Reporter Assay showed upregulation of Notch signaling activity after overexpression of activated Notch1. 293 H cells were transfected with RBP-Jκ reporter, negative control, and positive control. After 24 hours, cells were infected with 100 MOI of recombinant adenoviruses expressing activated Notch1 (Ad-NICD) or 100 MOI of recombinant adenovirus expressing GFP (Ad-GFP) for another 18 hours. Dual-luciferase assays were performed. Reporter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate and the standard deviation is shown.

3
Verification of small molecule drug candidate.

Cignal Retinoic Acid Response Element (RARE) Reporter Assay reported elevated retinoic acid receptor pathway activity after the treatment of all trans-retinoic acid (ATRA). CHO-K1 cells were transfected with RARE reporter, negative control, and positive control. After 16 hours, medium was changed to assay medium. After 24 hours, cells were treated with 1 µM all trans-rectinoic acid (ATRA) for 6 hours. Dual-luciferase assay was performed, and promoter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate and the standard deviation is shown.

4
Cignal Reporter Assay shows that hTNFa activated NFkB signaling pathway.
293 H cells were transfected with the Cignal NFkB-GFP Reporter Assay or negative control. After 16 hours, medium was changed to assay medium. After 24 hours, cells were treated with 10 ng/ml TNFα. After 18 hours, medium was removed from the wells and fluorescence activity was measured using a fluorometer. The fluorescence activity present in treated and nontreated negative control wells was subtracted from the fluorescence activity in treated and nontreated Cignal NFkB-GFP Reporter Assay wells and relative fluorescence activities expressed as arbitrary units. Experiments were performed in triplicate and the standard deviations are shown.
5
Cignal Reporter Assay measures activation of serum response factor (SRF) transcription activity.

293 H cells were transfected with the Cignal SRF-GFP Reporter Assay or negative control. After 16 hours, medium was changed to assay medium. After 24 hours, cells were treated with 10 ng/ml PMA and 10% serum. After 18 hours, medium was removed from the wells and fluorescence activity was measured using a fluorometer. The fluorescence activity present in treated and nontreated negative control wells was subtracted from the fluorescence activity in treated and nontreated Cignal SRF-GFP Reporter Assay wells and relative fluorescence activities expressed as arbitrary units. Experiments were performed in triplicate and the standard deviations are shown.

6
Cignal Reporter Assay procedure.
7
Cignal Reporter Assay principle.
Performance
Principle

Cignal Reporter Assays consist of multiple repeats of a specific transcription factor’s binding site and basic promoter elements to drive the expression of a reporter gene (firefly luciferase or GFP). These reporters are powerful tools in functional genomics and drug discovery for assessing pathway activity. When the pathway is activated or inhibited by a drug candidate, gene knockdown, overexpression, or peptide, luciferase or GFP reporter activity is modulated and can be measured quantitatively and rapidly (see figure "Cignal Reporter Assay principle"). The Cignal Reporter Assays are available as transfection-ready constructs utilizing two reporter systems: the dual-luciferase reporter or the GFP reporter (see flowchart "Cignal Reporter Assay procedure").

The dual-luciferase format is an end-point assay providing unsurpassed sensitivity, specificity, and signal-to-noise ratios. This format is available for all Cignal Reporter Assays. Each assay includes a pathway-focused transcription factor reporter and a noninducible negative control, as well as luciferase and GFP positive controls.

The GFP format is an outstanding method for monitoring live cell pathway regulation, with single cell resolution. It includes a pathway-focused transcription factor reporter and positive and negative controls.

Procedure

Cignal Reporter Assays include a preformulated, transfection-ready pathway reporter (dual-luciferase or GFP), plus a positive and negative control. The inducible pathway reporter and noninducible negative control are transfected and subjected to experimental treatments in parallel.

Dual-luciferase

Dual-luciferase results are calculated for each transfectant. The change in the activity of each signaling pathway is determined by comparing the normalized luciferase activities of the reporter in treated versus untreated transfectants. The identically treated negative control transfectants serve as a specificity control. The positive control serves as a control for transfection efficiency, by monitoring firefly luciferase and Renilla expression.

GFP

GFP expression is quantified using a flow cytometer, fluorescence microscope, or fluorometer. The change in the activity of each signaling pathway is determined by comparing the GFP activities in treated versus untreated transfectants. The identically treated negative control transfectants serve as a specificity control. The positive control serves as a control for transfection efficiency, by monitoring GFP expression from the constitutively expressing CMV-GFP reporter.

Applications

Cignal Reporter Assays are powerful tools in functional genomics, proteomics, and drug discovery for assessing the biological impact of pathway inhibition or activation with siRNAs, proteins, and small molecule compounds.

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Brochures & Guides (1)
For cell-based analysis of pathway signaling activity
Show details
Kit Handbooks (1)
Transfection Protocols (2)
Search for transfection data by nucleic acid, cell line, and transfection reagent. Our database contains data from researchers like yourself who have shared their experimental results with us.
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Transfection protocols for specific cell types and plate formats that save you the time and effort of adapting existing protocols to fit your requirements. Simply select the cell type, nucleic acid, and culture format to receive a QIAGEN transfection protocol to print out or download in convenient PDF format.
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p53 Reporter Assay Kit Cignal Reporter Assay Kits
Introduction
The Cignal p53 Reporter Assay Kit is designed to monitor the activity of p53-regulated signal transduction pathways in cultured cells. p53 signaling plays an important role in DNA repair, cell cycle arrest, and apoptosis. The p53 reporter acts as a sensor for p53 signaling. It is a mixture of inducible p53-responsive luciferase construct and constitutively expressing Renilla construct (40:1). The p53-responsive luciferase construct encodes the firefly luciferase reporter gene under the control of a minimal (m)CMV promoter and tandem repeats of the p53 transcriptional response element. We have experimentally optimized the number of response elements as well as the intervening sequence between response elements to maximize the signal to noise ratio. This construct monitors both increases and decreases in transcriptional activity of p53. The constitutively expressing Renilla construct encodes the Renilla luciferase reporter gene under the control of a CMV immediately early enhancer/promoter and acts as an internal control for normalizing transfection efficiencies and monitoring cell viability. Using a simple dual-luciferase assay, you can easily monitor the activity of p53-mediated signaling pathways and determine the effect of various treatments, such as gene knockdown, over-expression, and chemical compounds on those pathways.
CCS-004L

The Cignal p53 Reporter Assay demonstrates upregulation of p53 signaling activity. 293-H cells were transfected with the Cignal p53 Reporter, negative control, and positive control (for the transfection protocol, refer to the Cignal Reporter Assay Handbook). After 16 hours of transfection, medium was changed to assay medium (Opti-MEM + 0.5% FBS + 0.1 mM NEAA + 1 mM sodium pyruvate + 100 U/ml penicillin + 100 µg/ml streptomycin). After 24 hours of transfection, cells were treated separately with 100 µM nutlin (a small-molecule compound and well-known MDM-2 antagonist) or DMSO alone. A dual-luciferase assay was performed 18 hours after treatment, and promoter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate, and the standard deviation is indicated. The Cignal p53 Reporter Assay measured a 260-fold increase in p53 transcription activity by 100 µM nutlin.
Name Cignal p53 Pathway Reporter Assay Kit (LUC) (CCS-004L)
Official symbol Cdc25c [Mouse]
Official name cell division cycle 25C
Species Mouse (Mus musculus)
Entrez Gene ID 12532
Transcript(s) for this gene NM_009860 (1945 bp), XM_006525550 (2538 bp), XM_006525551 (2317 bp), XM_006525552 (2746 bp), XM_011246819 (1139 bp)
Official symbol Cdc25a [Mouse]
Official name cell division cycle 25A
Species Mouse (Mus musculus)
Entrez Gene ID 12530
Transcript(s) for this gene NM_007658 (3643 bp), XM_006511929 (3895 bp), XM_006511930 (3895 bp), XM_006511931 (3858 bp)
Official symbol Dkk1 [Mouse]
Official name dickkopf WNT signaling pathway inhibitor 1
Species Mouse (Mus musculus)
Entrez Gene ID 13380
Transcript(s) for this gene NM_010051 (2245 bp)
Official symbol Pcbp4 [Mouse]
Official name poly(rC) binding protein 4
Species Mouse (Mus musculus)
Entrez Gene ID 59092
Transcript(s) for this gene NM_021567 (2099 bp), XM_975004 (1078 bp), XM_006511779 (2204 bp), XM_006511780 (2218 bp), XM_006511781 (1860 bp), XM_006511782 (1134 bp), XM_006511783 (1134 bp)
Official symbol Serpinb5 [Mouse]
Official name serine (or cysteine) peptidase inhibitor, clade B, member 5
Species Mouse (Mus musculus)
Entrez Gene ID 20724
Transcript(s) for this gene NM_009257 (2565 bp), XM_006529290 (2636 bp), XM_006529291 (2760 bp)
Official symbol Ier3 [Mouse]
Official name immediate early response 3
Species Mouse (Mus musculus)
Entrez Gene ID 15937
Transcript(s) for this gene NM_133662 (1090 bp)
Official symbol Ccng1 [Mouse]
Official name cyclin G1
Species Mouse (Mus musculus)
Entrez Gene ID 12450
Transcript(s) for this gene NM_009831 (3501 bp), ENSMUST00000151359, XM_011248706 (914 bp)
Official symbol Gadd45a [Mouse]
Official name growth arrest and DNA-damage-inducible 45 alpha
Species Mouse (Mus musculus)
Entrez Gene ID 13197
Transcript(s) for this gene NM_007836 (1224 bp), ENSMUST00000155041, ENSMUST00000128617
Official symbol Cryz [Mouse]
Official name crystallin, zeta
Species Mouse (Mus musculus)
Entrez Gene ID 12972
Transcript(s) for this gene NM_009968 (2558 bp), ENSMUST00000135723, XM_006500973 (2277 bp)
Official symbol Gml [Mouse]
Official name GPI anchored molecule like protein
Species Mouse (Mus musculus)
Entrez Gene ID 625599
Transcript(s) for this gene NM_001177524 (895 bp), XM_001475491 (225 bp), XM_001476885 (807 bp), XM_001476898 (225 bp), XM_890177 (955 bp), XM_909667 (681 bp), XM_006521229 (1531 bp), XM_006521230 (969 bp), XM_006521231 (986 bp), XM_006521232 (913 bp), XM_006521233 (1381 bp)
Official symbol E2f1 [Mouse]
Official name E2F transcription factor 1
Species Mouse (Mus musculus)
Entrez Gene ID 13555
Transcript(s) for this gene NM_007891 (2739 bp), NM_001291105 (2695 bp), XM_006498694 (2502 bp)
Official symbol Cdkn1a [Mouse]
Official name cyclin-dependent kinase inhibitor 1A (P21)
Species Mouse (Mus musculus)
Entrez Gene ID 12575
Transcript(s) for this gene NM_001111099 (1943 bp), NM_007669 (1913 bp)
Official symbol P2rx6 [Mouse]
Official name purinergic receptor P2X, ligand-gated ion channel, 6
Species Mouse (Mus musculus)
Entrez Gene ID 18440
Transcript(s) for this gene NM_001159561 (2281 bp), NM_011028 (2362 bp), XM_006521856 (1106 bp), XR_384534 (0 bp)
Official symbol Tnfrsf10b [Mouse]
Official name tumor necrosis factor receptor superfamily, member 10b
Species Mouse (Mus musculus)
Entrez Gene ID 21933
Transcript(s) for this gene NM_020275 (3197 bp)
Official symbol Ctsd [Mouse]
Official name cathepsin D
Species Mouse (Mus musculus)
Entrez Gene ID 13033
Transcript(s) for this gene NM_009983 (1979 bp), ENSMUST00000153679
Official symbol Scara3 [Mouse]
Official name scavenger receptor class A, member 3
Species Mouse (Mus musculus)
Entrez Gene ID 219151
Transcript(s) for this gene NM_172604 (3405 bp)
Official symbol Met [Mouse]
Official name met proto-oncogene
Species Mouse (Mus musculus)
Entrez Gene ID 17295
Transcript(s) for this gene NM_008591 (6652 bp), ENSMUST00000145473, XM_006505002 (6729 bp), XM_011241042 (6761 bp), XM_011241043 (6438 bp)
Official symbol Anln [Mouse]
Official name anillin, actin binding protein
Species Mouse (Mus musculus)
Entrez Gene ID 68743
Transcript(s) for this gene NM_028390 (5421 bp), XM_006510581 (5096 bp), XM_006510582 (4142 bp), XM_011242594 (3200 bp)
Official symbol Pcna [Mouse]
Official name proliferating cell nuclear antigen
Species Mouse (Mus musculus)
Entrez Gene ID 18538
Transcript(s) for this gene ENSMUST00000149627, ENSMUST00000135181, NM_011045 (1260 bp)
Official symbol Plk2 [Mouse]
Official name polo-like kinase 2
Species Mouse (Mus musculus)
Entrez Gene ID 20620
Transcript(s) for this gene NM_152804 (2802 bp)
Official symbol Fas [Mouse]
Official name Fas (TNF receptor superfamily member 6)
Species Mouse (Mus musculus)
Entrez Gene ID 14102
Transcript(s) for this gene NM_001146708 (555 bp), NM_007987 (1486 bp), XM_011247141 (1496 bp)
Official symbol Myc [Mouse]
Official name myelocytomatosis oncogene
Species Mouse (Mus musculus)
Entrez Gene ID 17869
Transcript(s) for this gene NM_001177352 (2399 bp), NM_001177353 (2396 bp), NM_001177354 (2396 bp), NM_010849 (2399 bp)
Official symbol Cd82 [Mouse]
Official name CD82 antigen
Species Mouse (Mus musculus)
Entrez Gene ID 12521
Transcript(s) for this gene NM_001136055 (1701 bp), NM_007656 (1833 bp), NM_001271430 (1757 bp), NM_001271431 (1625 bp), NM_001271432 (1920 bp), NM_001271461 (1712 bp), NM_001271462 (1724 bp), ENSMUST00000144168, XM_006498652 (1667 bp)
Official symbol Il6 [Mouse]
Official name interleukin 6
Species Mouse (Mus musculus)
Entrez Gene ID 16193
Transcript(s) for this gene NM_001314054 (1083 bp), NM_031168 (1141 bp)
Official symbol Bax [Mouse]
Official name BCL2-associated X protein
Species Mouse (Mus musculus)
Entrez Gene ID 12028
Transcript(s) for this gene NM_007527 (869 bp), XM_011250780 (918 bp), XM_006540584 (860 bp)
Official symbol Tnf [Mouse]
Official name tumor necrosis factor
Species Mouse (Mus musculus)
Entrez Gene ID 21926
Transcript(s) for this gene NM_013693 (1653 bp), NM_001278601 (1605 bp)
Official symbol Esr1 [Mouse]
Official name estrogen receptor 1 (alpha)
Species Mouse (Mus musculus)
Entrez Gene ID 13982
Transcript(s) for this gene NM_007956 (6248 bp), XM_985634 (3048 bp), XM_985672 (6199 bp), XM_985704 (6760 bp), ENSMUST00000149195, XM_006512432 (6377 bp), XM_006512433 (6250 bp), XM_006512434 (6173 bp), XM_006512435 (6123 bp), XM_006512436 (2916 bp), NM_001302531 (6218 bp), NM_001302532 (6358 bp), NM_001302533 (2730 bp), XM_011243066 (6188 bp), XM_011243067 (6189 bp), XM_011243068 (6158 bp), XM_011243069 (1346 bp)
Official symbol Rrm2b [Mouse]
Official name ribonucleotide reductase M2 B (TP53 inducible)
Species Mouse (Mus musculus)
Entrez Gene ID 382985
Transcript(s) for this gene NM_199476 (4532 bp), ENSMUST00000127362, XM_006520101 (4698 bp), XM_006520102 (4639 bp), XM_006520103 (1315 bp), XM_011245361 (1807 bp)
Official symbol Pttg1 [Mouse]
Official name pituitary tumor-transforming gene 1
Species Mouse (Mus musculus)
Entrez Gene ID 30939
Transcript(s) for this gene ENSMUST00000150726, XM_006533515 (702 bp), XM_006533516 (700 bp), NM_013917 (1698 bp), NM_001131054 (748 bp)
Official symbol Bbc3 [Mouse]
Official name BCL2 binding component 3
Species Mouse (Mus musculus)
Entrez Gene ID 170770
Transcript(s) for this gene ENSMUST00000147267, XM_006539575 (1735 bp), XM_006539576 (2317 bp), XM_006539577 (2150 bp), XM_006539578 (1756 bp), XM_006539579 (1642 bp), XM_006539580 (1794 bp), XM_006539581 (1979 bp), XM_006539582 (1592 bp), XM_006539583 (1613 bp), XM_006539584 (1430 bp), XM_983526 (1945 bp), NM_133234 (1976 bp)
Official symbol Slc38a2 [Mouse]
Official name solute carrier family 38, member 2
Species Mouse (Mus musculus)
Entrez Gene ID 67760
Transcript(s) for this gene XM_006521300 (4543 bp), NM_175121 (4645 bp)
Official symbol Bdkrb2 [Mouse]
Official name bradykinin receptor, beta 2
Species Mouse (Mus musculus)
Entrez Gene ID 12062
Transcript(s) for this gene NM_009747 (1680 bp), XM_006515440 (3795 bp), XM_006515441 (3816 bp), XM_006515442 (3951 bp)
Official symbol Mdm2 [Mouse]
Official name transformed mouse 3T3 cell double minute 2
Species Mouse (Mus musculus)
Entrez Gene ID 17246
Transcript(s) for this gene NM_010786 (3124 bp), ENSMUST00000151725, NM_001288586 (3039 bp), XM_006513311 (3060 bp), XM_006513310 (3010 bp), XM_011243378 (3140 bp)
Official symbol Mmp2 [Mouse]
Official name matrix metallopeptidase 2
Species Mouse (Mus musculus)
Entrez Gene ID 17390
Transcript(s) for this gene XM_006530751 (3203 bp), NM_008610 (3078 bp)
Official symbol Sesn2 [Mouse]
Official name sestrin 2
Species Mouse (Mus musculus)
Entrez Gene ID 230784
Transcript(s) for this gene NM_144907 (2677 bp)
Official symbol Thbs2 [Mouse]
Official name thrombospondin 2
Species Mouse (Mus musculus)
Entrez Gene ID 21826
Transcript(s) for this gene NM_011581 (5922 bp)
Official symbol Igfbp3 [Mouse]
Official name insulin-like growth factor binding protein 3
Species Mouse (Mus musculus)
Entrez Gene ID 16009
Transcript(s) for this gene XM_011243665 (2359 bp), XM_990107 (1339 bp), XM_001001532 (1486 bp), NM_008343 (2456 bp)
Official symbol Scd1 [Mouse]
Official name stearoyl-Coenzyme A desaturase 1
Species Mouse (Mus musculus)
Entrez Gene ID 20249
Transcript(s) for this gene NM_009127 (4844 bp)
Official symbol Hgf [Mouse]
Official name hepatocyte growth factor
Species Mouse (Mus musculus)
Entrez Gene ID 15234
Transcript(s) for this gene NM_010427 (2810 bp), XM_131908 (3092 bp), NM_001289458 (2838 bp), NM_001289459 (2827 bp), NM_001289460 (2143 bp), NM_001289461 (2645 bp), XM_006535628 (5828 bp), XM_006535629 (6013 bp), XM_006535630 (5856 bp), XM_011249748 (5939 bp)
Official symbol Tgfa [Mouse]
Official name transforming growth factor alpha
Species Mouse (Mus musculus)
Entrez Gene ID 21802
Transcript(s) for this gene NM_031199 (4547 bp)
Official symbol Odc1 [Mouse]
Official name ornithine decarboxylase, structural 1
Species Mouse (Mus musculus)
Entrez Gene ID 18263
Transcript(s) for this gene NM_013614 (2547 bp)
Official symbol Tap1 [Mouse]
Official name transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Species Mouse (Mus musculus)
Entrez Gene ID 21354
Transcript(s) for this gene ENSMUST00000168351, ENSMUST00000166287, NM_013683 (2950 bp), NM_001161730 (2866 bp)
Official symbol Ppm1d [Mouse]
Official name protein phosphatase 1D magnesium-dependent, delta isoform
Species Mouse (Mus musculus)
Entrez Gene ID 53892
Transcript(s) for this gene XM_988873 (2951 bp), XM_001002394 (2663 bp), NM_016910 (2911 bp)
Official symbol Serpine1 [Mouse]
Official name serine (or cysteine) peptidase inhibitor, clade E, member 1
Species Mouse (Mus musculus)
Entrez Gene ID 18787
Transcript(s) for this gene NM_008871 (3024 bp)
Official symbol Casp9 [Mouse]
Official name caspase 9
Species Mouse (Mus musculus)
Entrez Gene ID 12371
Transcript(s) for this gene NM_015733 (3899 bp), ENSMUST00000138359, NM_001277932 (3789 bp)
Official symbol Trp73 [Mouse]
Official name transformation related protein 73
Species Mouse (Mus musculus)
Entrez Gene ID 22062
Transcript(s) for this gene XM_006538720 (4771 bp), XM_006538721 (4495 bp), XM_006538722 (4604 bp), XM_006538723 (4125 bp), XM_989340 (4779 bp), NM_011642 (5046 bp), NM_001126331 (4468 bp), NM_001126330 (4756 bp)
Official symbol Gdf15 [Mouse]
Official name growth differentiation factor 15
Species Mouse (Mus musculus)
Entrez Gene ID 23886
Transcript(s) for this gene NM_011819 (1084 bp), XM_011242304 (1361 bp), XM_006509669 (1367 bp)
Official symbol Sfn [Mouse]
Official name stratifin
Species Mouse (Mus musculus)
Entrez Gene ID 55948
Transcript(s) for this gene NM_018754 (1616 bp)
Official symbol Cx3cl1 [Mouse]
Official name chemokine (C-X3-C motif) ligand 1
Species Mouse (Mus musculus)
Entrez Gene ID 20312
Transcript(s) for this gene ENSMUST00000151783, NM_009142 (3144 bp)
Official symbol Eef1a1 [Mouse]
Official name eukaryotic translation elongation factor 1 alpha 1
Species Mouse (Mus musculus)
Entrez Gene ID 13627
Transcript(s) for this gene ENSMUST00000150960, NM_010106 (1790 bp)
Official symbol Apaf1 [Mouse]
Official name apoptotic peptidase activating factor 1
Species Mouse (Mus musculus)
Entrez Gene ID 11783
Transcript(s) for this gene ENSMUST00000161095, NM_001282947 (6497 bp), NM_009684 (6514 bp), NM_001042558 (6557 bp)
Official symbol Brca1 [Mouse]
Official name breast cancer 1, early onset
Species Mouse (Mus musculus)
Entrez Gene ID 12189
Transcript(s) for this gene NM_009764 (6648 bp), ENSMUST00000156843, XM_006532064 (6519 bp), XM_006532065 (4803 bp), XM_006532066 (3161 bp), XM_006532067 (4204 bp), XM_006532068 (3338 bp)
Official symbol Prkca [Mouse]
Official name protein kinase C, alpha
Species Mouse (Mus musculus)
Entrez Gene ID 18750
Transcript(s) for this gene NM_011101 (8385 bp), ENSMUST00000134910
Official symbol Btg2 [Mouse]
Official name B cell translocation gene 2, anti-proliferative
Species Mouse (Mus musculus)
Entrez Gene ID 12227
Transcript(s) for this gene NM_007570 (3083 bp)
Official symbol Nos3 [Mouse]
Official name nitric oxide synthase 3, endothelial cell
Species Mouse (Mus musculus)
Entrez Gene ID 18127
Transcript(s) for this gene XM_006535639 (3925 bp), NM_008713 (4140 bp)
Official symbol Trpm2 [Mouse]
Official name transient receptor potential cation channel, subfamily M, member 2
Species Mouse (Mus musculus)
Entrez Gene ID 28240
Transcript(s) for this gene ENSMUST00000154996, NM_138301 (7292 bp), XM_006513733 (3054 bp), XM_006513732 (3850 bp), XM_006513731 (3875 bp), XM_006513730 (3529 bp), XM_006513729 (4587 bp)
Official symbol E2f3 [Mouse]
Official name E2F transcription factor 3
Species Mouse (Mus musculus)
Entrez Gene ID 13557
Transcript(s) for this gene XM_011244275 (6201 bp), XM_011244276 (6189 bp), XM_011244277 (4607 bp), XM_006516542 (6093 bp), NM_001289920 (4588 bp), XM_127250 (5091 bp), NM_010093 (5106 bp)
Official symbol Rb1 [Mouse]
Official name retinoblastoma 1
Species Mouse (Mus musculus)
Entrez Gene ID 19645
Transcript(s) for this gene NM_009029 (4642 bp), ENSMUST00000170967, XM_006518731 (2420 bp), XR_383150 (3088 bp), XR_383151 (2889 bp)
Official symbol Hspa8 [Mouse]
Official name heat shock protein 8
Species Mouse (Mus musculus)
Entrez Gene ID 15481
Transcript(s) for this gene ENSMUST00000153847, NR_015570 (2104 bp), NM_031165 (2104 bp)
Official symbol Pidd1 [Mouse]
Official name p53 induced death domain protein 1
Species Mouse (Mus musculus)
Entrez Gene ID 57913
Transcript(s) for this gene NM_022654 (2900 bp), ENSMUST00000154949, XM_011249848 (3733 bp), XM_011249849 (2518 bp), XM_006536221 (3274 bp), XM_006536220 (3935 bp), XM_006536219 (2518 bp), XM_006536218 (3730 bp)
Official symbol S100a2 [Mouse]
Official name S100 calcium binding protein A2
Species Mouse (Mus musculus)
Entrez Gene ID 628324
Transcript(s) for this gene XM_006501848 (553 bp), NM_001195760 (315 bp), XM_001478157 (315 bp), XM_893062 (1482 bp), XM_910611 (330 bp), XM_990199 (330 bp), XM_994606 (240 bp)
Official symbol Egfr [Mouse]
Official name epidermal growth factor receptor
Species Mouse (Mus musculus)
Entrez Gene ID 13649
Transcript(s) for this gene NM_007912 (2678 bp), NM_207655 (5983 bp), ENSMUST00000139722, XM_006514491 (6041 bp)
Official symbol Btg2 [Rat]
Official name BTG family, member 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 29619
Transcript(s) for this gene NM_017259 (2519 bp)
Official symbol Slc38a2 [Rat]
Official name solute carrier family 38, member 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 29642
Transcript(s) for this gene NM_181090 (4632 bp), XM_006242282 (4751 bp), XM_006242283 (4635 bp)
Official symbol Bbc3 [Rat]
Official name Bcl-2 binding component 3
Species Rat (Rattus norvegicus)
Entrez Gene ID 317673
Transcript(s) for this gene NM_173837 (1823 bp)
Official symbol Sfn [Rat]
Official name stratifin
Species Rat (Rattus norvegicus)
Entrez Gene ID 313017
Transcript(s) for this gene XM_001065560 (1516 bp), XM_232745 (1077 bp), XM_003750048 (1516 bp)
Official symbol Apaf1 [Rat]
Official name apoptotic peptidase activating factor 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 78963
Transcript(s) for this gene XM_008765263 (6465 bp), NM_023979 (6111 bp)
Official symbol Cdc25c [Rat]
Official name cell division cycle 25C
Species Rat (Rattus norvegicus)
Entrez Gene ID 307511
Transcript(s) for this gene XM_226071 (1362 bp), XM_001061940 (1368 bp), NM_001107396 (2068 bp), XM_008772039 (2990 bp), XM_006254580 (3015 bp), XM_006254579 (3078 bp)
Official symbol Rrm2b [Rat]
Official name ribonucleotide reductase M2 B (TP53 inducible)
Species Rat (Rattus norvegicus)
Entrez Gene ID 299976
Transcript(s) for this gene NM_001130543 (1204 bp), XM_001061249 (1233 bp), XM_235367 (1158 bp)
Official symbol Tnfrsf10b [Rat]
Official name tumor necrosis factor receptor superfamily, member 10b
Species Rat (Rattus norvegicus)
Entrez Gene ID 364420
Transcript(s) for this gene NM_001108873 (2107 bp), XM_001069338 (1056 bp), XM_344431 (1314 bp)
Official symbol Anlnl1 [Rat]
Official name anillin, actin binding protein-like 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 307056
Transcript(s) for this gene XM_001067026 (3234 bp), XM_225479 (2916 bp), XM_008774021 (4228 bp), XM_008771846 (4099 bp), XM_006222448 (4138 bp)
Official symbol Hspa8 [Rat]
Official name heat shock 70kDa protein 8
Species Rat (Rattus norvegicus)
Entrez Gene ID 24468
Transcript(s) for this gene XM_001053026 (2113 bp), NM_024351 (2130 bp)
Official symbol Pidd1 [Rat]
Official name p53-induced death domain protein 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 293625
Transcript(s) for this gene NM_001106318 (3321 bp), XM_001062274 (3253 bp), XM_002725753 (3202 bp), XM_002728843 (3202 bp), XM_219485 (3253 bp), XM_347291 (2745 bp), XM_008759984 (3869 bp), XM_008759983 (4485 bp), XM_006230544 (4437 bp), XM_006230543 (3963 bp)
Official symbol Egfr [Rat]
Official name epidermal growth factor receptor
Species Rat (Rattus norvegicus)
Entrez Gene ID 24329
Transcript(s) for this gene NM_031507 (4161 bp), XM_008770416 (9579 bp), XM_008770417 (9537 bp), XM_008770418 (3800 bp)
Official symbol E2f3 [Rat]
Official name E2F transcription factor 3
Species Rat (Rattus norvegicus)
Entrez Gene ID 291105
Transcript(s) for this gene NM_001137626 (2020 bp), XM_214476 (1802 bp), XR_008490 (2921 bp)
Official symbol Rb1 [Rat]
Official name retinoblastoma 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 24708
Transcript(s) for this gene NM_017045 (4711 bp), XM_001071121 (4566 bp), XM_344434 (4694 bp)
Official symbol Prkca [Rat]
Official name protein kinase C, alpha
Species Rat (Rattus norvegicus)
Entrez Gene ID 24680
Transcript(s) for this gene NM_001105713 (3702 bp), XM_001081588 (4227 bp), XM_343975 (3785 bp), XM_008768310 (8686 bp)
Official symbol Trpm2 [Rat]
Official name transient receptor potential cation channel, subfamily M, member 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 294329
Transcript(s) for this gene NM_001011559 (4527 bp), XM_228069 (4527 bp), XM_006256248 (5546 bp), XM_006256249 (5543 bp), XM_008772811 (4172 bp)
Official symbol Cx3cl1 [Rat]
Official name C-X3-C motif chemokine ligand 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 89808
Transcript(s) for this gene NM_134455 (3044 bp), XM_008772329 (3802 bp)
Official symbol Brca1 [Rat]
Official name breast cancer 1, early onset
Species Rat (Rattus norvegicus)
Entrez Gene ID 497672
Transcript(s) for this gene NM_012514 (5607 bp), XM_579334 (5607 bp), XM_008768092 (6850 bp)
Official symbol Tp73 [Rat]
Official name tumor protein p73
Species Rat (Rattus norvegicus)
Entrez Gene ID 362675
Transcript(s) for this gene NM_001108696 (4749 bp), XM_001077013 (2991 bp), XM_342992 (1809 bp)
Official symbol Gdf15 [Rat]
Official name growth differentiation factor 15
Species Rat (Rattus norvegicus)
Entrez Gene ID 29455
Transcript(s) for this gene NM_019216 (912 bp)
Official symbol Casp9 [Rat]
Official name caspase 9, apoptosis-related cysteine peptidase
Species Rat (Rattus norvegicus)
Entrez Gene ID 58918
Transcript(s) for this gene NM_031632 (2391 bp)
Official symbol Scd [Rat]
Official name stearoyl-CoA desaturase (delta-9-desaturase)
Species Rat (Rattus norvegicus)
Entrez Gene ID 83792
Transcript(s) for this gene NM_031841 (5055 bp)
Official symbol Serpine1 [Rat]
Official name serpin family E member 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 24617
Transcript(s) for this gene NM_012620 (3053 bp)
Official symbol Nos3 [Rat]
Official name nitric oxide synthase 3, endothelial cell
Species Rat (Rattus norvegicus)
Entrez Gene ID 24600
Transcript(s) for this gene NM_021838 (3953 bp), XM_006235872 (4162 bp)
Official symbol Ppm1d [Rat]
Official name protein phosphatase, Mg2+/Mn2+ dependent, 1D
Species Rat (Rattus norvegicus)
Entrez Gene ID 287585
Transcript(s) for this gene NM_001105825 (2909 bp), XM_001081120 (3087 bp), XM_213418 (3087 bp)
Official symbol Tgfa [Rat]
Official name transforming growth factor alpha
Species Rat (Rattus norvegicus)
Entrez Gene ID 24827
Transcript(s) for this gene NM_012671 (4222 bp), XM_006236822 (1520 bp), XM_008763049 (1524 bp), XM_008763050 (3165 bp)
Official symbol Cdkn1a [Rat]
Official name cyclin-dependent kinase inhibitor 1A
Species Rat (Rattus norvegicus)
Entrez Gene ID 114851
Transcript(s) for this gene NM_080782 (1894 bp), XM_006256128 (1937 bp)
Official symbol Tap1 [Rat]
Official name transporter 1, ATP binding cassette subfamily B member
Species Rat (Rattus norvegicus)
Entrez Gene ID 24811
Transcript(s) for this gene NM_032055 (2693 bp)
Official symbol Odc1 [Rat]
Official name ornithine decarboxylase 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 24609
Transcript(s) for this gene NM_012615 (2423 bp), NM_001302083 (2393 bp), XM_006239907 (2457 bp), XM_006239908 (2373 bp), XM_006239906 (0 bp)
Official symbol Hgf [Rat]
Official name hepatocyte growth factor
Species Rat (Rattus norvegicus)
Entrez Gene ID 24446
Transcript(s) for this gene NM_017017 (2532 bp), XM_006235979 (3814 bp)
Official symbol Eef1a1 [Rat]
Official name eukaryotic translation elongation factor 1 alpha 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 171361
Transcript(s) for this gene NM_175838 (1737 bp)
Official symbol Igfbp3 [Rat]
Official name insulin-like growth factor binding protein 3
Species Rat (Rattus norvegicus)
Entrez Gene ID 24484
Transcript(s) for this gene NM_012588 (2416 bp), XM_001053435 (2291 bp)
Official symbol Mmp2 [Rat]
Official name matrix metallopeptidase 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 81686
Transcript(s) for this gene NM_031054 (3053 bp)
Official symbol Thbs2 [Rat]
Official name thrombospondin 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 292406
Transcript(s) for this gene NM_001169138 (5728 bp), XM_001055515 (5727 bp), XM_214778 (5937 bp)
Official symbol Bdkrb2 [Rat]
Official name bradykinin receptor B2
Species Rat (Rattus norvegicus)
Entrez Gene ID 25245
Transcript(s) for this gene NM_173100 (3937 bp), NM_001270713 (4111 bp)
Official symbol Mdm2 [Rat]
Official name MDM2 proto-oncogene, E3 ubiquitin protein ligase
Species Rat (Rattus norvegicus)
Entrez Gene ID 314856
Transcript(s) for this gene NM_001108099 (2855 bp), XM_001080981 (2988 bp), XM_235169 (3135 bp), XM_006241382 (3226 bp), XM_006241383 (2790 bp), XM_008765396 (3298 bp), XM_008765397 (2862 bp), XM_008765399 (2608 bp)
Official symbol Esr1 [Rat]
Official name estrogen receptor 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 24890
Transcript(s) for this gene NM_012689 (2090 bp), XM_006227832 (6792 bp), XM_008758703 (6840 bp), XM_008758704 (6764 bp)
Official symbol Pttg1 [Rat]
Official name pituitary tumor-transforming 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 64193
Transcript(s) for this gene NM_022391 (959 bp), XM_006246142 (768 bp), XM_006246143 (965 bp), XM_006246144 (1062 bp), XM_006246145 (987 bp), XM_008767643 (717 bp)
Official symbol Bax [Rat]
Official name BCL2 associated X, apoptosis regulator
Species Rat (Rattus norvegicus)
Entrez Gene ID 24887
Transcript(s) for this gene NM_017059 (865 bp)
Official symbol Tnf [Rat]
Official name tumor necrosis factor
Species Rat (Rattus norvegicus)
Entrez Gene ID 24835
Transcript(s) for this gene NM_012675 (1687 bp)
Official symbol Cd82 [Rat]
Official name Cd82 molecule
Species Rat (Rattus norvegicus)
Entrez Gene ID 83628
Transcript(s) for this gene NM_031797 (1838 bp), XM_006234597 (1894 bp), XM_006234598 (1708 bp), XM_008762039 (1613 bp)
Official symbol Il6 [Rat]
Official name interleukin 6
Species Rat (Rattus norvegicus)
Entrez Gene ID 24498
Transcript(s) for this gene NM_012589 (1045 bp)
Official symbol Fas [Rat]
Official name Fas cell surface death receptor
Species Rat (Rattus norvegicus)
Entrez Gene ID 246097
Transcript(s) for this gene NM_139194 (2554 bp)
Official symbol Myc [Rat]
Official name myelocytomatosis oncogene
Species Rat (Rattus norvegicus)
Entrez Gene ID 24577
Transcript(s) for this gene NM_012603 (2355 bp)
Official symbol Plk2 [Rat]
Official name polo-like kinase 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 83722
Transcript(s) for this gene NM_031821 (2781 bp)
Official symbol Pcna [Rat]
Official name proliferating cell nuclear antigen
Species Rat (Rattus norvegicus)
Entrez Gene ID 25737
Transcript(s) for this gene NM_022381 (1160 bp)
Official symbol Met [Rat]
Official name MET proto-oncogene, receptor tyrosine kinase
Species Rat (Rattus norvegicus)
Entrez Gene ID 24553
Transcript(s) for this gene NM_031517 (4187 bp), XM_006236129 (6726 bp)
Official symbol Scara3 [Rat]
Official name scavenger receptor class A, member 3
Species Rat (Rattus norvegicus)
Entrez Gene ID 364405
Transcript(s) for this gene NM_001108870 (3358 bp), XM_001066917 (2619 bp), XM_344421 (2618 bp)
Official symbol Ctsd [Rat]
Official name cathepsin D
Species Rat (Rattus norvegicus)
Entrez Gene ID 171293
Transcript(s) for this gene NM_134334 (2060 bp)
Official symbol P2rx6 [Rat]
Official name purinergic receptor P2X, ligand-gated ion channel, 6
Species Rat (Rattus norvegicus)
Entrez Gene ID 25041
Transcript(s) for this gene NM_012721 (2331 bp), XM_008768851 (2559 bp), XM_008768852 (2244 bp)
Official symbol E2f1 [Rat]
Official name E2F transcription factor 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 399489
Transcript(s) for this gene NM_001100778 (2643 bp), XM_001065036 (2778 bp), XM_230765 (2643 bp), XM_008762363 (2640 bp)
Official symbol Gml [Rat]
Official name glycosylphosphatidylinositol anchored molecule like
Species Rat (Rattus norvegicus)
Entrez Gene ID 300019
Transcript(s) for this gene XM_001073772 (525 bp), XM_235422 (525 bp), XM_006226120 (1803 bp), XM_006226121 (1787 bp), XM_006226122 (1692 bp), XM_006241753 (1692 bp), XM_008765620 (2123 bp), XM_008765621 (1706 bp)
Official symbol Cryz [Rat]
Official name crystallin, zeta (quinone reductase)
Species Rat (Rattus norvegicus)
Entrez Gene ID 362061
Transcript(s) for this gene NM_001012183 (1924 bp), XM_342363 (1063 bp), XM_006233520 (2170 bp)
Official symbol Gadd45a [Rat]
Official name growth arrest and DNA-damage-inducible, alpha
Species Rat (Rattus norvegicus)
Entrez Gene ID 25112
Transcript(s) for this gene NM_024127 (1237 bp)
Official symbol Ccng1 [Rat]
Official name cyclin G1
Species Rat (Rattus norvegicus)
Entrez Gene ID 25405
Transcript(s) for this gene NM_012923 (3198 bp)
Official symbol Ier3 [Rat]
Official name immediate early response 3
Species Rat (Rattus norvegicus)
Entrez Gene ID 294235
Transcript(s) for this gene NM_212505 (1114 bp)
Official symbol Serpinb5 [Rat]
Official name serpin family B member 5
Species Rat (Rattus norvegicus)
Entrez Gene ID 116589
Transcript(s) for this gene NM_057108 (2576 bp), XM_008769405 (2738 bp)
Official symbol Pcbp4 [Rat]
Official name poly(rC) binding protein 4
Species Rat (Rattus norvegicus)
Entrez Gene ID 363133
Transcript(s) for this gene NM_001191883 (2022 bp), XM_001071111 (2007 bp), XM_343468 (2022 bp), XM_006243802 (2518 bp), XM_006243803 (2320 bp)
Official symbol Dkk1 [Rat]
Official name dickkopf WNT signaling pathway inhibitor 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 293897
Transcript(s) for this gene NM_001106350 (2295 bp), XM_001079710 (1442 bp), XM_219804 (1442 bp)
Official symbol Cdc25a [Rat]
Official name cell division cycle 25A
Species Rat (Rattus norvegicus)
Entrez Gene ID 171102
Transcript(s) for this gene NM_133571 (3415 bp), XM_006243703 (3218 bp), XM_006243702 (3667 bp)
Official symbol PCBP4 [Human]
Official name poly(rC) binding protein 4
Species Human (Homo sapiens)
Entrez Gene ID 57060
Transcript(s) for this gene NM_001174100 (2188 bp), NM_020418 (1962 bp), NM_033008 (2040 bp), NM_033009 (2458 bp), NM_033010 (1982 bp), ENST00000498822, XM_005265330 (2029 bp), XM_005265331 (2098 bp), XM_005265332 (1900 bp), XM_006713266 (2538 bp), XM_006713267 (2391 bp), XM_006713268 (3903 bp), XM_006713269 (2243 bp), XM_006713270 (1886 bp), XM_006713271 (1832 bp), ENST00000322099, ENST00000355852, ENST00000395014, ENST00000428823, ENST00000461554, ENST00000471622, ENST00000484633
Official symbol CDC25A [Human]
Official name cell division cycle 25A
Species Human (Homo sapiens)
Entrez Gene ID 993
Transcript(s) for this gene NM_001789 (3717 bp), NM_201567 (3597 bp), ENST00000459900, XM_006713434 (3684 bp), XM_006713435 (3564 bp), XM_006713436 (1297 bp), ENST00000302506, ENST00000351231
Official symbol TP53I3 [Human]
Official name tumor protein p53 inducible protein 3
Species Human (Homo sapiens)
Entrez Gene ID 9540
Transcript(s) for this gene NM_001206802 (961 bp), NM_004881 (2042 bp), NM_147184 (1643 bp), ENST00000470636, ENST00000238721, ENST00000335934, ENST00000407482, XM_006712150 (1438 bp), XM_005264650 (1507 bp)
Official symbol SERPINB5 [Human]
Official name serpin peptidase inhibitor, clade B (ovalbumin), member 5
Species Human (Homo sapiens)
Entrez Gene ID 5268
Transcript(s) for this gene NM_002639 (2633 bp), ENST00000588986, XM_006722483 (2141 bp), ENST00000382771, ENST00000489441
Official symbol DKK1 [Human]
Official name dickkopf WNT signaling pathway inhibitor 1
Species Human (Homo sapiens)
Entrez Gene ID 22943
Transcript(s) for this gene NM_012242 (1815 bp), ENST00000494277, ENST00000373970
Official symbol IER3 [Human]
Official name immediate early response 3
Species Human (Homo sapiens)
Entrez Gene ID 8870
Transcript(s) for this gene NM_003897 (1254 bp), NM_052815 (1345 bp), ENST00000259874, ENST00000376377
Official symbol CCNG1 [Human]
Official name cyclin G1
Species Human (Homo sapiens)
Entrez Gene ID 900
Transcript(s) for this gene NM_004060 (2484 bp), NM_199246 (2384 bp), ENST00000514367, ENST00000340828, ENST00000393929, ENST00000504553, ENST00000510664, ENST00000512163
Official symbol GADD45A [Human]
Official name growth arrest and DNA-damage-inducible, alpha
Species Human (Homo sapiens)
Entrez Gene ID 1647
Transcript(s) for this gene NM_001199741 (1296 bp), NM_001199742 (1160 bp), NM_001924 (1398 bp), ENST00000484245, ENST00000370985, ENST00000370986, ENST00000617962
Official symbol CRYZ [Human]
Official name crystallin, zeta (quinone reductase)
Species Human (Homo sapiens)
Entrez Gene ID 1429
Transcript(s) for this gene NM_001130042 (2317 bp), NM_001130043 (2176 bp), NM_001134759 (1990 bp), NM_001889 (2278 bp), ENST00000492102, XM_005270491 (1815 bp), ENST00000340866, ENST00000370871, ENST00000370872, ENST00000417775
Official symbol GML [Human]
Official name glycosylphosphatidylinositol anchored molecule like
Species Human (Homo sapiens)
Entrez Gene ID 2765
Transcript(s) for this gene NM_002066 (723 bp), ENST00000220940
Official symbol E2F1 [Human]
Official name E2F transcription factor 1
Species Human (Homo sapiens)
Entrez Gene ID 1869
Transcript(s) for this gene NM_005225 (2722 bp), ENST00000343380
Official symbol P2RX6 [Human]
Official name purinergic receptor P2X, ligand-gated ion channel, 6
Species Human (Homo sapiens)
Entrez Gene ID 9127
Transcript(s) for this gene NM_001159554 (2698 bp), NM_005446 (2754 bp), ENST00000591411, ENST00000401443, ENST00000413302, XM_006724370 (2696 bp), XM_006724369 (2643 bp), XM_005261819 (2721 bp)
Official symbol SCARA3 [Human]
Official name scavenger receptor class A, member 3
Species Human (Homo sapiens)
Entrez Gene ID 51435
Transcript(s) for this gene NM_016240 (3631 bp), NM_182826 (1711 bp), XM_005273527 (3661 bp), ENST00000301904, ENST00000337221
Official symbol CTSD [Human]
Official name cathepsin D
Species Human (Homo sapiens)
Entrez Gene ID 1509
Transcript(s) for this gene NM_001909 (2141 bp), ENST00000497544, ENST00000236671
Official symbol MET [Human]
Official name MET proto-oncogene, receptor tyrosine kinase
Species Human (Homo sapiens)
Entrez Gene ID 4233
Transcript(s) for this gene NM_000245 (6641 bp), NM_001127500 (6695 bp), ENST00000495962, XM_006715988 (6547 bp), XM_006715989 (6493 bp), XM_006715990 (5311 bp), XM_006715991 (5456 bp), ENST00000318493, ENST00000397752, ENST00000436117
Official symbol ANLN [Human]
Official name anillin, actin binding protein
Species Human (Homo sapiens)
Entrez Gene ID 54443
Transcript(s) for this gene NM_018685 (4804 bp), ENST00000495714, NM_001284301 (4693 bp), NM_001284302 (4690 bp), XM_006715746 (4841 bp), XM_006715747 (4730 bp), ENST00000265748, ENST00000396068
Official symbol PCNA [Human]
Official name proliferating cell nuclear antigen
Species Human (Homo sapiens)
Entrez Gene ID 5111
Transcript(s) for this gene NM_002592 (1355 bp), NM_182649 (1319 bp), ENST00000379143, ENST00000379160
Official symbol CDC25C [Human]
Official name cell division cycle 25C
Species Human (Homo sapiens)
Entrez Gene ID 995
Transcript(s) for this gene NM_001790 (2191 bp), NM_022809 (1972 bp), ENST00000504831, NM_001287582 (2187 bp), NM_001287583 (2304 bp), XM_005272145 (2175 bp), XM_005272146 (2141 bp), XM_006714739 (1893 bp), XM_006714740 (1593 bp), ENST00000323760, ENST00000348983, ENST00000415130, ENST00000513970, ENST00000514555
Official symbol PLK2 [Human]
Official name polo like kinase 2
Species Human (Homo sapiens)
Entrez Gene ID 10769
Transcript(s) for this gene NM_001252226 (2808 bp), NM_006622 (2850 bp), ENST00000515415, ENST00000509422, ENST00000274289, ENST00000617412
Official symbol MYC [Human]
Official name v-myc avian myelocytomatosis viral oncogene homolog
Species Human (Homo sapiens)
Entrez Gene ID 4609
Transcript(s) for this gene NM_002467 (2379 bp), XM_001129520 (567 bp), XM_001129632 (567 bp), ENST00000259523, ENST00000377970, ENST00000524013, ENST00000613283, ENST00000621592
Official symbol FAS [Human]
Official name Fas cell surface death receptor
Species Human (Homo sapiens)
Entrez Gene ID 355
Transcript(s) for this gene NM_000043 (2755 bp), NM_152871 (2692 bp), NM_152872 (2730 bp), NM_152873 (2646 bp), NM_152874 (2563 bp), NM_152875 (2583 bp), NM_152876 (2445 bp), NM_152877 (2508 bp), NR_028033 (2583 bp), NR_028034 (2445 bp), NR_028035 (2508 bp), NR_028036 (2646 bp), XM_006717819 (7250 bp), ENST00000352159, ENST00000355279, ENST00000355740, ENST00000357339, ENST00000612663, ENST00000615406, ENST00000626542
Official symbol CD82 [Human]
Official name CD82 molecule
Species Human (Homo sapiens)
Entrez Gene ID 3732
Transcript(s) for this gene NM_001024844 (1640 bp), NM_002231 (1715 bp), ENST00000530931, XM_006718222 (2219 bp), XM_006718223 (2196 bp), ENST00000227155, ENST00000342935
Official symbol IL6 [Human]
Official name interleukin 6
Species Human (Homo sapiens)
Entrez Gene ID 3569
Transcript(s) for this gene NM_000600 (1201 bp), ENST00000485300, XM_005249745 (1412 bp), ENST00000258743, ENST00000401630, ENST00000401651, ENST00000404625, ENST00000406575, ENST00000407492
Official symbol ESR1 [Human]
Official name estrogen receptor 1
Species Human (Homo sapiens)
Entrez Gene ID 2099
Transcript(s) for this gene NM_000125 (6330 bp), NM_001122740 (6357 bp), NM_001122741 (6314 bp), NM_001122742 (6466 bp), ENST00000488573, NM_001291230 (6320 bp), NM_001291241 (6311 bp), XM_006715374 (6282 bp), XM_006715375 (5809 bp), ENST00000206249, ENST00000338799, ENST00000406599, ENST00000427531, ENST00000440973, ENST00000443427, ENST00000456483
Official symbol TNF [Human]
Official name tumor necrosis factor
Species Human (Homo sapiens)
Entrez Gene ID 7124
Transcript(s) for this gene NM_000594 (1686 bp), ENST00000449264
Official symbol BAX [Human]
Official name BCL2-associated X protein
Species Human (Homo sapiens)
Entrez Gene ID 581
Transcript(s) for this gene NM_004324 (891 bp), NM_138761 (888 bp), NM_138762 (195 bp), NM_138763 (741 bp), NM_138764 (849 bp), NM_138765 (849 bp), NR_027882 (986 bp), NM_001291428 (869 bp), NM_001291429 (839 bp), NM_001291430 (692 bp), NM_001291431 (621 bp), XM_006723314 (750 bp), ENST00000293288, ENST00000345358, ENST00000354470, ENST00000391871, ENST00000415969, ENST00000539787
Official symbol BBC3 [Human]
Official name BCL2 binding component 3
Species Human (Homo sapiens)
Entrez Gene ID 27113
Transcript(s) for this gene NM_001127240 (1839 bp), NM_001127241 (1550 bp), NM_001127242 (1359 bp), NM_014417 (1853 bp), ENST00000601438, XM_005258740 (1596 bp), XM_006723141 (1649 bp), ENST00000300880, ENST00000341983, ENST00000439096, ENST00000449228
Official symbol PTTG1 [Human]
Official name pituitary tumor-transforming 1
Species Human (Homo sapiens)
Entrez Gene ID 9232
Transcript(s) for this gene NM_004219 (786 bp), ENST00000524244, NM_001282382 (1093 bp), NM_001282383 (947 bp), ENST00000352433, ENST00000393964, ENST00000520452
Official symbol RRM2B [Human]
Official name ribonucleotide reductase M2 B (TP53 inducible)
Species Human (Homo sapiens)
Entrez Gene ID 50484
Transcript(s) for this gene NM_001172477 (4913 bp), NM_001172478 (4776 bp), NM_015713 (4932 bp), ENST00000519125, ENST00000251810, ENST00000395912, ENST00000519317, ENST00000519962, ENST00000621845
Official symbol MMP2 [Human]
Official name matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Species Human (Homo sapiens)
Entrez Gene ID 4313
Transcript(s) for this gene NM_001127891 (3416 bp), NM_004530 (3558 bp), NM_001302508 (3230 bp), NM_001302509 (3159 bp), NM_001302510 (3152 bp), ENST00000219070, ENST00000437642, ENST00000543485, ENST00000570308
Official symbol MDM2 [Human]
Official name MDM2 proto-oncogene, E3 ubiquitin protein ligase
Species Human (Homo sapiens)
Entrez Gene ID 4193
Transcript(s) for this gene NM_001145336 (7234 bp), NM_001145337 (7104 bp), NM_001145339 (7330 bp), NM_001145340 (6657 bp), NM_002392 (7495 bp), NM_006878 (6625 bp), NM_006879 (6155 bp), NM_006880 (1490 bp), NM_006881 (6552 bp), NM_006882 (6415 bp), ENST00000544125, NM_001278462 (6735 bp), XM_005268872 (1923 bp), XM_006719399 (1709 bp), XM_006719400 (1975 bp), ENST00000258148, ENST00000258149, ENST00000299252, ENST00000348801, ENST00000350057, ENST00000356290, ENST00000360430, ENST00000393410, ENST00000393412, ENST00000393413, ENST00000428863, ENST00000462284, ENST00000478070, ENST00000517852, ENST00000544561, ENST00000545204
Official symbol BDKRB2 [Human]
Official name bradykinin receptor B2
Species Human (Homo sapiens)
Entrez Gene ID 624
Transcript(s) for this gene NM_000623 (4197 bp), ENST00000539359, ENST00000542454, ENST00000554311
Official symbol IGFBP3 [Human]
Official name insulin-like growth factor binding protein 3
Species Human (Homo sapiens)
Entrez Gene ID 3486
Transcript(s) for this gene NM_000598 (2620 bp), NM_001013398 (2638 bp), ENST00000465642, ENST00000275521, ENST00000381083, ENST00000381086, ENST00000613132, ENST00000615754
Official symbol THBS2 [Human]
Official name thrombospondin 2
Species Human (Homo sapiens)
Entrez Gene ID 7058
Transcript(s) for this gene NM_003247 (5898 bp), ENST00000488355, ENST00000366787, ENST00000617924
Official symbol SESN2 [Human]
Official name sestrin 2
Species Human (Homo sapiens)
Entrez Gene ID 83667
Transcript(s) for this gene NM_031459 (3547 bp), ENST00000253063
Official symbol SCD [Human]
Official name stearoyl-CoA desaturase (delta-9-desaturase)
Species Human (Homo sapiens)
Entrez Gene ID 6319
Transcript(s) for this gene NM_005063 (5473 bp), ENST00000370355
Official symbol EEF1A1 [Human]
Official name eukaryotic translation elongation factor 1 alpha 1
Species Human (Homo sapiens)
Entrez Gene ID 1915
Transcript(s) for this gene NM_001402 (3528 bp), ENST00000495333, ENST00000309268, ENST00000316292, ENST00000331523, ENST00000610520, ENST00000615060
Official symbol HGF [Human]
Official name hepatocyte growth factor (hepapoietin A; scatter factor)
Species Human (Homo sapiens)
Entrez Gene ID 3082
Transcript(s) for this gene NM_000601 (2820 bp), NM_001010931 (1307 bp), NM_001010932 (2805 bp), NM_001010933 (1292 bp), NM_001010934 (2079 bp), ENST00000465234, XM_006715956 (4792 bp), ENST00000222390, ENST00000354224, ENST00000423064, ENST00000444829, ENST00000453018, ENST00000453411, ENST00000457544
Official symbol TAP1 [Human]
Official name transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Species Human (Homo sapiens)
Entrez Gene ID 6890
Transcript(s) for this gene NM_000593 (2974 bp), ENST00000487296, NM_001292022 (2234 bp), ENST00000354258
Official symbol TGFA [Human]
Official name transforming growth factor, alpha
Species Human (Homo sapiens)
Entrez Gene ID 7039
Transcript(s) for this gene NM_001099691 (4323 bp), NM_003236 (4326 bp), ENST00000474101, XM_005264522 (4473 bp), ENST00000295400, ENST00000418333, ENST00000444975, ENST00000445399, ENST00000450929
Official symbol PPM1D [Human]
Official name protein phosphatase, Mg2+/Mn2+ dependent, 1D
Species Human (Homo sapiens)
Entrez Gene ID 8493
Transcript(s) for this gene NM_003620 (4790 bp), ENST00000305921, ENST00000629650
Official symbol SERPINE1 [Human]
Official name serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Species Human (Homo sapiens)
Entrez Gene ID 5054
Transcript(s) for this gene NM_000602 (3207 bp), NM_001165413 (3153 bp), ENST00000223095
Official symbol CASP9 [Human]
Official name caspase 9, apoptosis-related cysteine peptidase
Species Human (Homo sapiens)
Entrez Gene ID 842
Transcript(s) for this gene NM_001229 (3038 bp), NM_032996 (2869 bp), NM_001278054 (2588 bp), XM_005246014 (1936 bp), NR_102732 (3096 bp), NR_102733 (2898 bp), ENST00000333868, ENST00000348549, ENST00000375890, ENST00000546424
Official symbol ODC1 [Human]
Official name ornithine decarboxylase 1
Species Human (Homo sapiens)
Entrez Gene ID 4953
Transcript(s) for this gene NM_002539 (2307 bp), ENST00000446285, NM_001287188 (2207 bp), NM_001287189 (2199 bp), NM_001287190 (2045 bp), ENST00000234111, ENST00000405333
Official symbol SFN [Human]
Official name stratifin
Species Human (Homo sapiens)
Entrez Gene ID 2810
Transcript(s) for this gene NM_006142 (1336 bp), ENST00000339276
Official symbol GDF15 [Human]
Official name growth differentiation factor 15
Species Human (Homo sapiens)
Entrez Gene ID 9518
Transcript(s) for this gene NM_004864 (1220 bp), ENST00000604609, ENST00000252809
Official symbol TP73 [Human]
Official name tumor protein p73
Species Human (Homo sapiens)
Entrez Gene ID 7161
Transcript(s) for this gene NM_001126240 (5131 bp), NM_001126241 (5037 bp), NM_001126242 (4982 bp), NM_001204184 (5060 bp), NM_001204185 (5005 bp), NM_001204186 (4772 bp), NM_001204187 (4911 bp), NM_001204188 (4866 bp), NM_001204189 (4749 bp), NM_001204190 (4888 bp), NM_001204191 (4843 bp), NM_001204192 (4964 bp), NM_005427 (5154 bp), ENST00000604566, ENST00000346387, ENST00000354437, ENST00000357733, ENST00000378280, ENST00000378285, ENST00000378288, ENST00000378290, ENST00000378295, ENST00000603362, ENST00000604074, ENST00000604479
Official symbol BRCA1 [Human]
Official name breast cancer 1, early onset
Species Human (Homo sapiens)
Entrez Gene ID 672
Transcript(s) for this gene NM_007294 (7224 bp), NM_007295 (7388 bp), NM_007296 (7185 bp), NM_007297 (7132 bp), NM_007298 (3699 bp), NM_007299 (3800 bp), NM_007300 (7287 bp), NM_007301 (6601 bp), NM_007302 (7068 bp), NM_007303 (3765 bp), NM_007304 (3879 bp), NM_007305 (3759 bp), NM_007306 (7307 bp), NR_027676 (7128 bp), XM_006722029 (7168 bp), XM_006722030 (7136 bp), XM_006722031 (7692 bp), XM_006722032 (7117 bp), XM_006722033 (7117 bp), XM_006722034 (7117 bp), XM_006722035 (7129 bp), XM_006722036 (6708 bp), XM_006722037 (3811 bp), XM_006722038 (3808 bp), XM_006722039 (3836 bp), XM_006722040 (3808 bp), XM_006722041 (3685 bp), ENST00000352993, ENST00000354071, ENST00000357654, ENST00000468300, ENST00000471181, ENST00000491747, ENST00000493795, ENST00000586385, ENST00000591534, ENST00000591849
Official symbol APAF1 [Human]
Official name apoptotic peptidase activating factor 1
Species Human (Homo sapiens)
Entrez Gene ID 317
Transcript(s) for this gene NM_001160 (7042 bp), NM_013229 (7171 bp), NM_181861 (7204 bp), NM_181868 (7075 bp), NM_181869 (4559 bp), ENST00000555047, ENST00000333991, ENST00000357310, ENST00000359972, ENST00000547045, ENST00000547743, ENST00000549007, ENST00000550527, ENST00000551964, ENST00000552268
Official symbol CX3CL1 [Human]
Official name chemokine (C-X3-C motif) ligand 1
Species Human (Homo sapiens)
Entrez Gene ID 6376
Transcript(s) for this gene NM_002996 (3304 bp), ENST00000006053, ENST00000563383, ENST00000564948, ENST00000565912
Official symbol TRPM2 [Human]
Official name transient receptor potential cation channel, subfamily M, member 2
Species Human (Homo sapiens)
Entrez Gene ID 7226
Transcript(s) for this gene NM_001001188 (5879 bp), NM_003307 (5876 bp), NR_038257 (5879 bp), XM_005261171 (5715 bp), XM_006724049 (5530 bp), XM_006724050 (3784 bp), ENST00000300481, ENST00000300482, ENST00000397928, ENST00000397932, ENST00000621064
Official symbol NOS3 [Human]
Official name nitric oxide synthase 3 (endothelial cell)
Species Human (Homo sapiens)
Entrez Gene ID 4846
Transcript(s) for this gene NM_000603 (4345 bp), NM_001160109 (2040 bp), NM_001160110 (2386 bp), NM_001160111 (2546 bp), ENST00000477227, ENST00000468293, XM_006716000 (4440 bp), XM_006716001 (3835 bp), XM_006716002 (2458 bp), ENST00000297494, ENST00000461406, ENST00000467517, ENST00000484524
Official symbol PRKCA [Human]
Official name protein kinase C, alpha
Species Human (Homo sapiens)
Entrez Gene ID 5578
Transcript(s) for this gene NM_002737 (8787 bp), ENST00000583775, XM_006721972 (3162 bp), ENST00000413366
Official symbol HSPA8 [Human]
Official name heat shock 70kDa protein 8
Species Human (Homo sapiens)
Entrez Gene ID 3312
Transcript(s) for this gene NM_006597 (2473 bp), NM_153201 (2014 bp), ENST00000533238, XM_006718831 (2191 bp), ENST00000227378, ENST00000453788, ENST00000526110, ENST00000532636, ENST00000533540, ENST00000534319, ENST00000534624
Official symbol RB1 [Human]
Official name retinoblastoma 1
Species Human (Homo sapiens)
Entrez Gene ID 5925
Transcript(s) for this gene NM_000321 (4772 bp), ENST00000531171, ENST00000267163
Official symbol E2F3 [Human]
Official name E2F transcription factor 3
Species Human (Homo sapiens)
Entrez Gene ID 1871
Transcript(s) for this gene NM_001243076 (4443 bp), NM_001949 (5027 bp), XM_005248865 (4375 bp), XM_005248866 (4326 bp), XM_005248868 (4186 bp), ENST00000346618, ENST00000535432, ENST00000613242
Official symbol CDKN1A [Human]
Official name cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Species Human (Homo sapiens)
Entrez Gene ID 1026
Transcript(s) for this gene NM_000389 (2175 bp), NM_001220777 (2119 bp), NM_001220778 (2284 bp), NM_078467 (2122 bp), NR_037150 (2327 bp), NR_037151 (2285 bp), NR_037152 (2120 bp), ENST00000478800, NM_001291549 (2325 bp), ENST00000244741, ENST00000373711, ENST00000405375, ENST00000448526, ENST00000615513
Official symbol TNFRSF10B [Human]
Official name tumor necrosis factor receptor superfamily, member 10b
Species Human (Homo sapiens)
Entrez Gene ID 8795
Transcript(s) for this gene NM_003842 (4154 bp), NM_147187 (4067 bp), NR_027140 (3961 bp), XM_006716409 (4124 bp), ENST00000276431, ENST00000347739
Official symbol BTG2 [Human]
Official name BTG family, member 2
Species Human (Homo sapiens)
Entrez Gene ID 7832
Transcript(s) for this gene NM_006763 (2718 bp), ENST00000290551
Official symbol TP53AIP1 [Human]
Official name tumor protein p53 regulated apoptosis inducing protein 1
Species Human (Homo sapiens)
Entrez Gene ID 63970
Transcript(s) for this gene NM_001195194 (600 bp), NM_001195195 (1255 bp), NM_001251964 (3158 bp), NM_022112 (1278 bp), ENST00000525390, ENST00000458238, ENST00000530777, ENST00000531399, ENST00000602346, ENST00000621818
Official symbol PIDD1 [Human]
Official name p53-induced death domain protein 1
Species Human (Homo sapiens)
Entrez Gene ID 55367
Transcript(s) for this gene NM_018494 (3046 bp), NM_145886 (3022 bp), NM_145887 (2971 bp), ENST00000534649, XM_005253005 (3698 bp), XM_005253006 (3261 bp), XM_005253007 (3011 bp), XM_005253008 (3758 bp), XM_006718258 (3647 bp), ENST00000347755, ENST00000411829
Official symbol SLC38A2 [Human]
Official name solute carrier family 38, member 2
Species Human (Homo sapiens)
Entrez Gene ID 54407
Transcript(s) for this gene NM_018976 (4961 bp), ENST00000553252, XM_005268983 (4680 bp), ENST00000256689, ENST00000551374, ENST00000612232
Official symbol S100A2 [Human]
Official name S100 calcium binding protein A2
Species Human (Homo sapiens)
Entrez Gene ID 6273
Transcript(s) for this gene NM_005978 (970 bp), ENST00000368707, ENST00000368708, ENST00000368709, ENST00000368710, ENST00000487430, ENST00000497140
Official symbol EGFR [Human]
Official name epidermal growth factor receptor
Species Human (Homo sapiens)
Entrez Gene ID 1956
Transcript(s) for this gene NM_005228 (5616 bp), NM_201282 (2239 bp), NM_201283 (1595 bp), NM_201284 (2865 bp), ENST00000485503, ENST00000275493, ENST00000342916, ENST00000344576, ENST00000420316, ENST00000442591, ENST00000454757, ENST00000455089