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Cignal Lenti Reporter Assays

For sensitive assessment of cell signaling activities in virtually any mammalian cell type

  • Transduce virtually any mammalian cell type
  • Transduce nondividing cells, stem cells, and differentiated cells
  • Use for transient experiments or develop stable cell line reporters
  • Transduction-ready lentivirus requires no further preparation

Cignal Lenti Reporter Assays are ready-to-transduce lentiviral particles for assessing cell signaling activities in virtually any mammalian cell type.

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Cignal Lenti Reporter Assays are intended for molecular biology applications. These products are not intended for the diagnosis, prevention, or treatment of a disease.


0
Determination of pathway activity in human primary cells.
The Cignal Lenti NFAT Reporter Assay was used to determine PKA/Ca2+ pathway activity. Cignal Lenti NFAT Reporter Assay (luc) (4 x 105 TU) and Cignal Lenti Renilla Control (luc) (1 x 105 TU) cotransduced around 10,000 normal human pulmonary artery smooth muscle cells (PASMC). After 48 hours transduction, medium was changed to assay medium. After 54 hours transduction, cells were treated with 10 ng/ml PMA and 0.5 µM ionomycin for 18 hours. Dual-luciferase assay was performed, and promoter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate and the standard deviation is shown.
1
Notch signaling activity in rat glioma cells.
The Cignal Lenti RBP-Jk Reporter Assay was used to measure Notch signaling activity in C6 (rat glioma) cells. Cignal Lenti RBP-Jk Reporter Assay (luc) (2 x 105 TU) and Cignal Lenti Renilla Control (luc; 2 x 104 TU) transduced around 20,000 C6 cells. After 24 hours transduction, medium was changed to complete medium. After 48 hours transduction, cells were infected with 100 MOI of recombinant adenoviruses expressing constitutive active Notch1 (Ad-NICD) or 100 MOI of recombinant adenovirus expressing GFP (Ad-GFP). Dual-luciferase assay was performed 18 hours after infection, and promoter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate and the standard deviation is shown.
2

Measurement of NFκB pathway activity.

The Cignal Lenti NFκB Reporter Assay was used to measure NFκB pathway activity in thymocytic cells (D1; Murine T-cell leukemia cells). Cignal Lenti NFκB Reporter Assay (luc) (2.5 x 105 TU) transduced around 10,000 D1 cells. After 48 hours transduction, cells were treated with 20 ng/ml recombinant mouse TNFα (hTNFα) protein for 18 hours. Luciferase assay was performed and promoter activity values are expressed as arbitrary units. Experiments were performed in triplicate and the standard deviation is shown.
3
Advantage of using dual luciferase system.
Cignal Lenti HIF-1 Reporter (luc) (1.5 x 105 TU) transduced around 15,000 HepG2 cells (24 hours before transduction 7,500 cells were plated per well of 96-well plate) with and without Cignal Lenti Renilla control (3 x 104 TU). After 42 hours of transduction, medium was changed to assay medium (Opti-MEM + 0.5% FBS + 0.1mM NEAA + 1mM Sodium pyruvate + 100 U/ml penicillin + 100 µg/ml streptomycin). After 48 hours of transduction, cells were treated with 300 µM of CoCl2 for 18 hours. Luciferase or dual-luciferase assay was performed, and promoter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were done in triplicates, and the standard deviation is indicated. The utilization of the dual-luciferase system (cotransduction of Cignal Lenti Renilla Control along with Cignal Lenti Reporter Assay (luc)) improves the fold induction change in hypoxia signaling activity, as normalization of firefly luciferase activity with Renilla luciferase activity corrects for cell death caused by the treatment.
4
Stable cell line generation
The Cignal Lenti NFkB Reporter Assay (luc) was used to generate an NFkB pathway sensor cell line for the study of the NFkB signal transduction pathway. The NFkB sensor cell line was developed by transduction of HEK-293 cells with the Cignal Lenti NFkB Reporter Assay (luc), followed by selection of a clonal population that maintained stable chromosomal integration of the lentiviral vector provirus and responded strongly to stimuli known to activate the NFkB pathway. The generation of stable HEK-293 NFkB sensor cell line was confirmed by testing the cell line with 10 ng/ml of recombinant hTNFα after 1, 5, 10, and 15 passages of the cell line. Stimulation of the NFkB pathway by hTNFα results in up to a 100-fold increase in expression of the reporter gene even after 2 months of cell culture.
5
Cignal Lenti Reporter Assay procedure.
6
Cignal Lenti Reporter Assay.
7
Cignal Lenti Reporter Assays.
Performance
Cignal Lenti Reporter Assays are highly suited for use in studies of cell signaling in primary cells, stem cells, and difficult-to-transfect cell lines (see figures "Determination of pathway activity in human primary cells", "Notch signaling activity in rat glioma cells", "Measurement of NFkB pathway activity" and "Advantage of using dual luciferase system"). They may also be used in the generation of stable cell lines (see figure "Stable cell line generation") and in high-throughput screening of siRNAs.
Principle

Cignal Lenti Reporter Assays utilize a unique combination of transcription factor reporter technology coupled with lentiviral delivery. Cignal Lenti Reporter Assays consist of multiple repeats of a specific transcription factor’s binding site and basic promoter elements to drive the expression of a reporter gene (firefly luciferase or GFP).

Lentiviruses are one of the most effective vehicles to introduce reporter constructs in almost all mammalian cells — including nondividing cells. A transduced lentiviralreporter construct is integrated into cellular genomic DNA and provides stable, long-term expression of a reporter gene.

These reporters are powerful tools in functional genomics and drug discovery for assessing pathway activity. When the pathway is activated or inhibited by a drug candidate, gene knockdown (using siRNA), overexpression event (expression vectors), or peptide, luciferase or GFP reporter activity is modulated and can be measured quantitatively and rapidly.

Safety

The Cignal Lenti Reporter Assays are ready-to-transduce, replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles (see figure "Cignal Lenti Reporter Assay" and table "Features of Cignal Lenti Reporter Assays"). The Cignal lentiviral particles are safe to use. It is recommended that they be treated as Risk Group Level 2 (RGL-2) organisms. Follow all published RGL-2 guidelines for handling and waste decontamination. Details on the requirements for creating a BSL-2 work environment are available in the U.S. Department of Health and Human Services publication Biosafety in Microbiological and Biomedical Laboratories, 4th edition.

The biosafety features engineered into these vectors include the following: 

A deletion in the promoter/enhancer region of the U3 portion of 3' LTR that ensures self-inactivation of the lentiviral construct after transduction and integration into the genomic DNA of target cells 
The Cignal Lenti Reporter Assay and plasmids express packaging proteins contain no significant areas of homology, minimizing any chance for recombination 
None of the HIV-1 genes (gag, pol, rev) are expressed in transduced cells, since they are expressed from packaging plasmids lacking packaging signal. Therefore, the lentiviral particles generated are replication-incompetent 
No virulence genes (vpr, vif, vpu, and nef) are present in the Cignal Lenti Reporter Assay

 

Features of Cignal Lenti Reporter Assays
FeatureFunction
RSV-5' LTR: Hybrid Rous Sarcoma Virus (RSV) enhancer/promoter-U5 long terminal repeat Permits viral packaging and reverse transcription of viral mRNA
Psi: Packaging signal Allows viral packaging
RRE: Rev response element Involved in packaging of viral transcript
Cppt: Central polypurine tract Involved in nuclear translocation and integration of transduced viral genome
Reporter gene (firefly luciferase or GFP) Allows quantification of transcription
hPGK: human phosphoglycerate kinase eukaryotic promoter Permits high-level expression of the mammalian selection marker (puromycin)
PuroR: puromycin resistance gene Can be used for mammalian selection
SIN/3' LTR: 3' self-inactivating long terminal repeat Modified 3' LTR that allows viral packaging but self-inactivates the 5' LTR for biosafety reasons, the element also contains a polyadenylation signal for efficient transcription termination
f1 ori: f1 origin of replication Allows episomal replication of plasmid in eukaryotic cells
AmpR: ampicillin resistance gene Allows selection of the plasmid in E. coli
TRE: Transcription response element Permits regulation of reporter gene expression by a specific transcription factor
TATA box Acts as an minimal promoter

Procedure

Cignal Lenti Reporter Assays are immediately ready for transduction, without the need to further generate or propagate lentivirus. These vectors are highly suited for transient transduction studies in difficult to transfect cells or for stable, pathway sensor cell line generation.

Transient pathway regulation studies in difficult-to-transfect cell lines

Target cells are transduced with the Cignal Lenti Reporter Assay. The cells are typically cultured for 24–48 hours to ensure lentivirus integration. The cultures are then treated with the biological agents of interest (siRNA, shRNA, chemical compound, viral expression vector, protein, or peptide). Reporter assays (firefly luciferase or GFP) are carried out 18–36 hours post-treatment, depending upon the treatment conditions (see flowchart "Cignal Lenti Reporter Assay procedure").

Stable pathway sensor cell line generation

Target cells are transduced with the Cignal Lenti Reporter Assay. Following transduction, the cells are cultured with puromycin selection to generate a homogenous population of transduced cells. If necessary, single-cell cloning may be carried out in order to isolate a clonal pathway sensor cell line. These pathway sensor cell lines serve as a valuable cell-based assay platform, for subsequent screening and mechanism of action studies.

Applications

Cignal Lenti Reporter Assays are powerful tools in functional genomics and drug discovery for assessing cell signaling activities in virtually any mammalian cell type. They are highly suited for assessing the biological impact of siRNAs, proteins, and small molecule compounds.

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Brochures & Guides (1)
For measurement of signaling pathways in any mammalian cell
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Kit Handbooks (1)
For lentiviral-based cell signaling activity assays
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GLI Reporter Assay (luc) Cignal Lenti Reporter Assays
Introduction
The Cignal Lenti Reporter Assays are self-inactivating replication incompetent viral particles. The lentiviral particles are ready to add directly to your cells. The Lenti GLI Reporter is a preparation of ready-to-transduce lentiviral particles for monitoring the activity of the hedgehog signaling pathway in virtually any mammalian cell. The Sonic hedgehog signaling pathway plays an important role in the development cancer, specifically brain and skin cancers. The Sonic hedgehog signaling pathway also plays a vital role in CNS development, including proliferation of neuronal precursor cells and cerebellum development.The Lenti GLI reporter is a preparation of replication incompetent, VSV-g pseudotyped lentivirus particles expressing the firefly luciferase gene under the control of a minimal (m)CMV promoter and tandem repeats of the GLI transcriptional response element (TRE). We have experimentally optimized the number of response elements as well as the intervening sequence between response elements to maximize the signal to noise ratio. Using a simple luciferase assay, you can easily monitor the activity of GLI-mediated signaling pathways and determine the effect of various treatments, such as gene knockdown, over-expression, and chemical compounds on those pathways.
CLS-3030L

The Cignal Lenti GLI Reporter Assay measures GLI transcription activity. Cignal Lenti GLI Reporter (luc) [5 x 105 TU] and Cignal Lenti Renilla control (luc) [2.5 x 104 TU] co-transduced approximately 104 NIH/3T3 cells (24 hours before transduction, 5000 cells were plated per well of a 96-well plate). After 18 hours of transduction, medium was changed to complete growth medium. After 24 hours of transduction, cells were transfected with 200 ng/well empty or Gli expression vector. After 18 hours of transfection, medium was changed to assay medium (DMEM + 1% NCS + 1% NEAA) and cells were treated with 4 μg/ml recombinant mSHH protein (recombinant mouse sonic hedgehog, amino-terminal peptide). A dual-luciferase assay was performed 72 hours after mSHH treatment and promoter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate, and the standard deviation is indicated.
Name Cignal Lenti GLI Reporter (luc) (CLS-3030L)
Official symbol Otx2 [Mouse]
Official name orthodenticle homeobox 2
Species Mouse (Mus musculus)
Entrez Gene ID 18424
Transcript(s) for this gene NM_144841 (2239 bp), NM_001286481 (2341 bp), NM_001286482 (2317 bp), NM_001286483 (2157 bp), XM_006518689 (2435 bp), XM_006518690 (4502 bp), XM_006518691 (2199 bp), XM_006518692 (2675 bp), XM_006518693 (2403 bp), XM_006518694 (4470 bp), XM_011244988 (2929 bp), XM_011244989 (2896 bp)
Official symbol Bmp8b [Mouse]
Official name bone morphogenetic protein 8b
Species Mouse (Mus musculus)
Entrez Gene ID 12164
Transcript(s) for this gene NM_007559 (2965 bp), ENSMUST00000151850, XM_011240420 (3764 bp)
Official symbol Bmp8a [Mouse]
Official name bone morphogenetic protein 8a
Species Mouse (Mus musculus)
Entrez Gene ID 12163
Transcript(s) for this gene NM_001256019 (2405 bp), NM_007558 (2366 bp), XM_989162 (2482 bp)
Official symbol Bmp6 [Mouse]
Official name bone morphogenetic protein 6
Species Mouse (Mus musculus)
Entrez Gene ID 12161
Transcript(s) for this gene NM_007556 (2996 bp)
Official symbol Csnk1d [Mouse]
Official name casein kinase 1, delta
Species Mouse (Mus musculus)
Entrez Gene ID 104318
Transcript(s) for this gene NM_027874 (3749 bp), NM_139059 (3686 bp), ENSMUST00000155070, XM_011248662 (1817 bp), XM_011248663 (1747 bp)
Official symbol Wnt16 [Mouse]
Official name wingless-type MMTV integration site family, member 16
Species Mouse (Mus musculus)
Entrez Gene ID 93735
Transcript(s) for this gene NM_053116 (1666 bp), XM_006505214 (4459 bp)
Official symbol Npc1l1 [Mouse]
Official name NPC1-like 1
Species Mouse (Mus musculus)
Entrez Gene ID 237636
Transcript(s) for this gene NM_207242 (4571 bp), XM_006514693 (3013 bp)
Official symbol Btrc [Mouse]
Official name beta-transducin repeat containing protein
Species Mouse (Mus musculus)
Entrez Gene ID 12234
Transcript(s) for this gene NM_001037758 (6358 bp), NM_009771 (6250 bp), NM_001286465 (6340 bp), NM_001286466 (6126 bp), XM_006526607 (6379 bp), XM_006526608 (6222 bp), XM_006526609 (6216 bp), XM_006526610 (6264 bp), XM_006526611 (6132 bp), XM_006526612 (6121 bp), XM_006526613 (6102 bp), XM_006526614 (6174 bp), XM_006526615 (6273 bp), XM_011247118 (6324 bp), XM_011247119 (6252 bp), XM_011247120 (6241 bp), XM_011247121 (6195 bp), XM_011247122 (6234 bp), XM_011247123 (6156 bp), XM_011247124 (6073 bp), XM_011247125 (6433 bp), XM_011247126 (6301 bp), XM_011247127 (6146 bp)
Official symbol Ctnnb1 [Mouse]
Official name catenin (cadherin associated protein), beta 1
Species Mouse (Mus musculus)
Entrez Gene ID 12387
Transcript(s) for this gene NM_001165902 (3440 bp), NM_007614 (3640 bp), ENSMUST00000156911, XM_006511927 (3523 bp)
Official symbol Csnk1g2 [Mouse]
Official name casein kinase 1, gamma 2
Species Mouse (Mus musculus)
Entrez Gene ID 103236
Transcript(s) for this gene NM_001159591 (2259 bp), NM_134002 (2436 bp), XM_006513010 (2292 bp), XM_006513011 (2408 bp)
Official symbol Wif1 [Mouse]
Official name Wnt inhibitory factor 1
Species Mouse (Mus musculus)
Entrez Gene ID 24117
Transcript(s) for this gene NM_011915 (2242 bp), XM_983228 (1511 bp), XM_983264 (2245 bp), XM_983301 (2287 bp), ENSMUST00000145691, XM_006513651 (2752 bp)
Official symbol Ift52 [Mouse]
Official name intraflagellar transport 52
Species Mouse (Mus musculus)
Entrez Gene ID 245866
Transcript(s) for this gene NM_172150 (2124 bp), ENSMUST00000152201, XM_006499541 (2407 bp)
Official symbol Wnt8b [Mouse]
Official name wingless-type MMTV integration site family, member 8B
Species Mouse (Mus musculus)
Entrez Gene ID 22423
Transcript(s) for this gene NM_011720 (3376 bp)
Official symbol Sufu [Mouse]
Official name suppressor of fused homolog (Drosophila)
Species Mouse (Mus musculus)
Entrez Gene ID 24069
Transcript(s) for this gene NM_001025391 (4522 bp), NM_015752 (4525 bp), ENSMUST00000144341
Official symbol Rab23 [Mouse]
Official name RAB23, member RAS oncogene family
Species Mouse (Mus musculus)
Entrez Gene ID 19335
Transcript(s) for this gene NM_001159729 (4209 bp), NM_008999 (4321 bp), ENSMUST00000151482, XM_006495801 (4050 bp), XM_006495802 (4057 bp)
Official symbol Fkbp8 [Mouse]
Official name FK506 binding protein 8
Species Mouse (Mus musculus)
Entrez Gene ID 14232
Transcript(s) for this gene NM_001111066 (1730 bp), NM_001199631 (1826 bp), NM_010223 (1727 bp), ENSMUST00000144766, XM_006509554 (1729 bp), XM_006509555 (1729 bp), XM_006509556 (2063 bp)
Official symbol Wnt3 [Mouse]
Official name wingless-type MMTV integration site family, member 3
Species Mouse (Mus musculus)
Entrez Gene ID 22415
Transcript(s) for this gene NM_009521 (3115 bp), XM_006533168 (1377 bp)
Official symbol Mtss1 [Mouse]
Official name metastasis suppressor 1
Species Mouse (Mus musculus)
Entrez Gene ID 211401
Transcript(s) for this gene NM_001146180 (4933 bp), NM_144800 (4975 bp), XM_006520707 (5283 bp), XM_006520708 (5259 bp), XM_006520709 (5228 bp), XM_006520710 (5148 bp), XM_006520711 (5086 bp), XM_006520712 (5087 bp), XM_006520713 (5503 bp), XM_006520714 (5017 bp), XM_006520715 (5491 bp), XM_006520716 (4954 bp), XM_006520717 (5338 bp), XM_006520718 (5211 bp), XM_011245540 (5499 bp), XM_011245541 (5486 bp), XM_011245542 (5454 bp), XM_011245543 (5219 bp), XM_011245544 (4539 bp), XM_011245545 (5304 bp), XM_011245546 (5563 bp), XM_011245547 (5551 bp), XM_011245548 (5028 bp)
Official symbol Wnt9b [Mouse]
Official name wingless-type MMTV integration site family, member 9B
Species Mouse (Mus musculus)
Entrez Gene ID 22412
Transcript(s) for this gene NM_011719 (4519 bp)
Official symbol Wnt9a [Mouse]
Official name wingless-type MMTV integration site family, member 9A
Species Mouse (Mus musculus)
Entrez Gene ID 216795
Transcript(s) for this gene NM_139298 (3318 bp), XM_006532855 (3388 bp)
Official symbol Hhip [Mouse]
Official name Hedgehog-interacting protein
Species Mouse (Mus musculus)
Entrez Gene ID 15245
Transcript(s) for this gene NM_020259 (9094 bp), ENSMUST00000155850, XM_006530702 (3172 bp)
Official symbol Ptch1 [Mouse]
Official name patched 1
Species Mouse (Mus musculus)
Entrez Gene ID 19206
Transcript(s) for this gene NM_008957 (4305 bp), XM_006517159 (9644 bp), XM_006517160 (7450 bp), XM_006517161 (7242 bp), XM_006517162 (6841 bp), XM_006517163 (7112 bp), XM_006517164 (5685 bp), XM_011244497 (5517 bp), XM_011244498 (7718 bp)
Official symbol Cep76 [Mouse]
Official name centrosomal protein 76
Species Mouse (Mus musculus)
Entrez Gene ID 225659
Transcript(s) for this gene NM_001081073 (3979 bp), XM_001001286 (3979 bp), XM_001001295 (3758 bp), XM_129027 (3979 bp), XM_902049 (3758 bp), XM_916353 (3979 bp), XM_924228 (3758 bp), XM_986721 (3575 bp), XM_006525898 (3166 bp), XM_006525899 (3176 bp)
Official symbol Ptchd2 [Mouse]
Official name patched domain containing 2
Species Mouse (Mus musculus)
Entrez Gene ID 242748
Transcript(s) for this gene NM_001083342 (8689 bp), XM_620145 (8719 bp), XM_894941 (8689 bp), XM_902178 (8604 bp), XM_905292 (8643 bp), XM_985961 (8707 bp), ENSMUST00000143851, XM_006535951 (3139 bp), XM_006538859 (3160 bp)
Official symbol Gli2 [Mouse]
Official name GLI-Kruppel family member GLI2
Species Mouse (Mus musculus)
Entrez Gene ID 14633
Transcript(s) for this gene NM_001081125 (6708 bp), XM_136212 (6708 bp), XM_911650 (6711 bp), XM_922107 (6489 bp), XM_973171 (6315 bp), XM_006529140 (7982 bp), XM_006529141 (6272 bp), XM_011247924 (7024 bp)
Official symbol Wnt5a [Mouse]
Official name wingless-type MMTV integration site family, member 5A
Species Mouse (Mus musculus)
Entrez Gene ID 22418
Transcript(s) for this gene NM_001256224 (3731 bp), NM_009524 (4354 bp), ENSMUST00000151929, XM_006518923 (5819 bp), XM_006518924 (5735 bp), XM_006518925 (5929 bp), XM_006518926 (5750 bp)
Official symbol Prkx [Mouse]
Official name protein kinase, X-linked
Species Mouse (Mus musculus)
Entrez Gene ID 19108
Transcript(s) for this gene NM_016979 (3217 bp), XM_006527909 (4505 bp), XM_006527910 (4384 bp)
Official symbol Sfrp1 [Mouse]
Official name secreted frizzled-related protein 1
Species Mouse (Mus musculus)
Entrez Gene ID 20377
Transcript(s) for this gene NM_013834 (4389 bp), XM_006509042 (4492 bp), XM_011242128 (4427 bp)
Official symbol Ptch2 [Mouse]
Official name patched 2
Species Mouse (Mus musculus)
Entrez Gene ID 19207
Transcript(s) for this gene NM_008958 (5119 bp), ENSMUST00000156989, NM_001312903 (5114 bp), XM_011240470 (4785 bp), XM_011240471 (4765 bp), XM_011240472 (3711 bp), XM_011240473 (3370 bp), XM_011240474 (3343 bp), XM_011240475 (4650 bp), XM_011240476 (3259 bp)
Official symbol Wnt7b [Mouse]
Official name wingless-type MMTV integration site family, member 7B
Species Mouse (Mus musculus)
Entrez Gene ID 22422
Transcript(s) for this gene NM_001163633 (3426 bp), NM_001163634 (3510 bp), NM_009528 (3389 bp)
Official symbol Stk36 [Mouse]
Official name serine/threonine kinase 36
Species Mouse (Mus musculus)
Entrez Gene ID 269209
Transcript(s) for this gene NM_175031 (5329 bp), ENSMUST00000157007, XM_006496039 (5234 bp), XM_006496040 (5085 bp)
Official symbol Erbb4 [Mouse]
Official name erb-b2 receptor tyrosine kinase 4
Species Mouse (Mus musculus)
Entrez Gene ID 13869
Transcript(s) for this gene NM_010154 (12037 bp), XM_001002143 (4257 bp), XM_136682 (4303 bp), XM_909965 (4303 bp), XM_986918 (4257 bp), XM_993491 (4257 bp), XM_993511 (4303 bp), ENSMUST00000131148, XM_006495692 (13098 bp), XM_006495693 (13068 bp), XM_006495694 (13019 bp), XM_006495695 (6841 bp), XM_006536907 (7478 bp), XM_011251207 (12821 bp)
Official symbol Wnt5b [Mouse]
Official name wingless-type MMTV integration site family, member 5B
Species Mouse (Mus musculus)
Entrez Gene ID 22419
Transcript(s) for this gene NM_009525 (2384 bp), NM_001271757 (2174 bp), NM_001271758 (2117 bp), XM_006505922 (2171 bp), XM_006505923 (2129 bp), XM_006505924 (2288 bp), XM_006505925 (2254 bp)
Official symbol Dhh [Mouse]
Official name desert hedgehog
Species Mouse (Mus musculus)
Entrez Gene ID 13363
Transcript(s) for this gene NM_007857 (2381 bp), XM_006520406 (2456 bp)
Official symbol Crim1 [Mouse]
Official name cysteine rich transmembrane BMP regulator 1 (chordin like)
Species Mouse (Mus musculus)
Entrez Gene ID 50766
Transcript(s) for this gene NM_015800 (5995 bp), XM_128751 (6230 bp), XM_006524601 (5815 bp), XM_006524602 (5571 bp), XM_006524603 (4721 bp)
Official symbol Zic2 [Mouse]
Official name zinc finger protein of the cerebellum 2
Species Mouse (Mus musculus)
Entrez Gene ID 22772
Transcript(s) for this gene NM_009574 (2967 bp), XM_981175 (2538 bp), XM_981308 (1527 bp), ENSMUST00000137059
Official symbol Gli1 [Mouse]
Official name GLI-Kruppel family member GLI1
Species Mouse (Mus musculus)
Entrez Gene ID 14632
Transcript(s) for this gene NM_010296 (3662 bp), XM_989852 (3249 bp), XM_011243372 (3566 bp)
Official symbol 3110002H16Rik [Mouse]
Official name RIKEN cDNA 3110002H16 gene
Species Mouse (Mus musculus)
Entrez Gene ID 76482
Transcript(s) for this gene NM_029623 (2134 bp), ENSMUST00000155431, XM_006526341 (2240 bp), XM_006526342 (2101 bp)
Official symbol Gli1 [Rat]
Official name GLI family zinc finger 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 140589
Transcript(s) for this gene NM_001191910 (3501 bp), XM_001056128 (3501 bp), XM_002726951 (3378 bp), XM_002729800 (3378 bp), XM_345832 (3501 bp), XM_006241442 (3765 bp), XM_006241443 (3648 bp), XM_008765375 (3713 bp)
Official symbol Crim1 [Rat]
Official name cysteine rich transmembrane BMP regulator 1 (chordin like)
Species Rat (Rattus norvegicus)
Entrez Gene ID 298744
Transcript(s) for this gene NM_001169103 (4076 bp), XM_001064272 (6429 bp), XM_233798 (4305 bp), XM_006239623 (6090 bp), XM_006239625 (5850 bp)
Official symbol Zic2 [Rat]
Official name Zic family member 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 361096
Transcript(s) for this gene NM_001108392 (2903 bp), XM_001075422 (3341 bp), XM_341381 (3327 bp)
Official symbol Lrp2 [Rat]
Official name LDL receptor related protein 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 29216
Transcript(s) for this gene NM_030827 (15438 bp)
Official symbol Bmp6 [Rat]
Official name bone morphogenetic protein 6
Species Rat (Rattus norvegicus)
Entrez Gene ID 25644
Transcript(s) for this gene NM_013107 (1521 bp)
Official symbol Mapk1 [Rat]
Official name mitogen activated protein kinase 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 116590
Transcript(s) for this gene NM_053842 (1467 bp), XM_006248658 (4970 bp), XM_006248659 (1470 bp), XM_008768848 (3690 bp)
Official symbol Grem1 [Rat]
Official name gremlin 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 50566
Transcript(s) for this gene NM_019282 (3809 bp)
Official symbol Npc1l1 [Rat]
Official name NPC1 like intracellular cholesterol transporter 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 432367
Transcript(s) for this gene NM_001002025 (4484 bp)
Official symbol Hhat [Rat]
Official name hedgehog acyltransferase
Species Rat (Rattus norvegicus)
Entrez Gene ID 289344
Transcript(s) for this gene XM_002724902 (2343 bp), XM_002728056 (2439 bp), XM_223026 (3888 bp), XR_008636 (2149 bp), XM_008764018 (3965 bp), XM_008769894 (3707 bp)
Official symbol Erbb4 [Rat]
Official name erb-b2 receptor tyrosine kinase 4
Species Rat (Rattus norvegicus)
Entrez Gene ID 59323
Transcript(s) for this gene NM_021687 (4060 bp)
Official symbol Wnt5b [Rat]
Official name wingless-type MMTV integration site family, member 5B
Species Rat (Rattus norvegicus)
Entrez Gene ID 282582
Transcript(s) for this gene NM_001100489 (2122 bp), XM_001057561 (2122 bp), XM_342747 (2122 bp), XM_006237179 (2000 bp)
Official symbol Wnt7b [Rat]
Official name wingless-type MMTV integration site family, member 7B
Species Rat (Rattus norvegicus)
Entrez Gene ID 315196
Transcript(s) for this gene NM_001009695 (1050 bp)
Official symbol Stk36 [Rat]
Official name serine/threonine kinase 36
Species Rat (Rattus norvegicus)
Entrez Gene ID 301516
Transcript(s) for this gene NM_001173986 (5031 bp), XM_001058046 (5031 bp), XM_217435 (5031 bp), XM_006245174 (5938 bp), XM_008767221 (4554 bp)
Official symbol Prkx [Rat]
Official name protein kinase, X-linked
Species Rat (Rattus norvegicus)
Entrez Gene ID 501563
Transcript(s) for this gene NM_001033963 (4078 bp), XM_576968 (654 bp)
Official symbol Sfrp1 [Rat]
Official name secreted frizzled-related protein 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 84402
Transcript(s) for this gene XM_001072532 (3506 bp), XM_224987 (3505 bp), NM_001276712 (3892 bp)
Official symbol Gli2 [Rat]
Official name GLI family zinc finger 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 304729
Transcript(s) for this gene NM_001107169 (6146 bp), XM_001053566 (6506 bp), XM_222557 (6506 bp), XM_008769455 (6694 bp)
Official symbol Wnt5a [Rat]
Official name wingless-type MMTV integration site family, member 5A
Species Rat (Rattus norvegicus)
Entrez Gene ID 64566
Transcript(s) for this gene NM_022631 (1980 bp), XM_006252664 (3729 bp), XM_006252665 (3691 bp), XM_008771007 (4567 bp)
Official symbol Cep76 [Rat]
Official name centrosomal protein 76
Species Rat (Rattus norvegicus)
Entrez Gene ID 291540
Transcript(s) for this gene NM_001100514 (2724 bp), XM_001067027 (3168 bp), XM_214549 (3168 bp), XM_006254858 (3880 bp), XM_008772118 (3283 bp)
Official symbol Ptchd2 [Rat]
Official name patched domain containing 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 313705
Transcript(s) for this gene NM_001107992 (4931 bp), XM_001075091 (5054 bp), XM_233671 (5054 bp), XM_003750087 (5803 bp), XM_003754115 (5803 bp)
Official symbol Hhip [Rat]
Official name Hedgehog-interacting protein
Species Rat (Rattus norvegicus)
Entrez Gene ID 291936
Transcript(s) for this gene NM_001191817 (2542 bp), XM_238042 (2542 bp)
Official symbol Ptch1 [Rat]
Official name patched 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 89830
Transcript(s) for this gene NM_053566 (4305 bp)
Official symbol Wnt9b [Rat]
Official name wingless-type MMTV integration site family, member 9B
Species Rat (Rattus norvegicus)
Entrez Gene ID 303586
Transcript(s) for this gene NM_001107055 (4658 bp), XM_001081544 (1241 bp), XM_221015 (1241 bp), XM_006247529 (3141 bp), XM_006247530 (3346 bp)
Official symbol Wnt9a [Rat]
Official name wingless-type MMTV integration site family, member 9A
Species Rat (Rattus norvegicus)
Entrez Gene ID 287357
Transcript(s) for this gene NM_001105783 (3337 bp), XM_001077006 (3265 bp), XM_220556 (3785 bp), XM_006246448 (3352 bp)
Official symbol Wnt3 [Rat]
Official name wingless-type MMTV integration site family, member 3
Species Rat (Rattus norvegicus)
Entrez Gene ID 24882
Transcript(s) for this gene NM_001105715 (2939 bp), XM_001081545 (1658 bp), XM_221016 (1658 bp), XM_008768262 (3173 bp)
Official symbol Mtss1 [Rat]
Official name metastasis suppressor 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 362918
Transcript(s) for this gene NM_001130563 (4691 bp), XM_001064860 (4437 bp), XM_343248 (4437 bp)
Official symbol Rab23 [Rat]
Official name RAB23, member RAS oncogene family
Species Rat (Rattus norvegicus)
Entrez Gene ID 367242
Transcript(s) for this gene NM_001109005 (2402 bp), XM_001054063 (1659 bp), XM_346033 (1659 bp), XM_008766955 (4995 bp), XM_008766956 (5000 bp), XM_008766957 (4320 bp), XM_008766958 (4662 bp), XM_008766959 (4993 bp), XM_008766960 (4988 bp), XM_008766961 (5711 bp)
Official symbol Fkbp8 [Rat]
Official name FK506 binding protein 8
Species Rat (Rattus norvegicus)
Entrez Gene ID 290652
Transcript(s) for this gene NM_001037180 (1679 bp), XM_214316 (1608 bp)
Official symbol Wnt8b [Rat]
Official name wingless-type MMTV integration site family, member 8B
Species Rat (Rattus norvegicus)
Entrez Gene ID 293990
Transcript(s) for this gene NM_001106359 (1456 bp), XM_001057370 (984 bp), XM_219959 (984 bp), XM_006231442 (1640 bp)
Official symbol Sufu [Rat]
Official name suppressor of fused homolog (Drosophila)
Species Rat (Rattus norvegicus)
Entrez Gene ID 361769
Transcript(s) for this gene NM_001024899 (1757 bp), XM_342061 (2357 bp), XM_006231546 (4509 bp), XM_008760443 (4518 bp)
Official symbol Wif1 [Rat]
Official name Wnt inhibitory factor 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 114557
Transcript(s) for this gene NM_053738 (2182 bp), XM_006241395 (2220 bp)
Official symbol Ift52 [Rat]
Official name intraflagellar transport 52
Species Rat (Rattus norvegicus)
Entrez Gene ID 362265
Transcript(s) for this gene NM_001177685 (2150 bp), XM_002726291 (2150 bp), XM_002729251 (2150 bp), XM_342571 (1345 bp), NM_001308389 (2083 bp)
Official symbol Fbxw11 [Rat]
Official name F-box and WD repeat domain containing 11
Species Rat (Rattus norvegicus)
Entrez Gene ID 303024
Transcript(s) for this gene NM_001106993 (3801 bp), XM_001063835 (4233 bp), XM_220281 (4119 bp), XM_006246092 (2113 bp), XM_006246093 (2104 bp), XM_006246094 (2041 bp)
Official symbol Csnk1g2 [Rat]
Official name casein kinase 1, gamma 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 65278
Transcript(s) for this gene NM_001033870 (2405 bp), NM_023102 (2271 bp), XM_001071924 (2272 bp), XM_001071962 (2245 bp), XM_001071997 (1837 bp), XM_001072038 (2232 bp), XM_006241000 (3752 bp), XM_006241001 (2329 bp), XM_006241002 (3672 bp), XM_006241003 (3102 bp), XM_008765130 (2460 bp)
Official symbol Btrc [Rat]
Official name beta-transducin repeat containing E3 ubiquitin protein ligase
Species Rat (Rattus norvegicus)
Entrez Gene ID 361765
Transcript(s) for this gene NM_001007148 (2334 bp), XM_006231529 (7232 bp), XM_006231530 (6643 bp), XM_006231531 (6609 bp), XM_006231535 (6494 bp), XM_006231536 (6576 bp), XM_006231537 (7123 bp), XM_006231538 (6533 bp), XM_006231539 (7279 bp), XM_006231541 (6993 bp), XM_006231543 (7201 bp)
Official symbol Wnt16 [Rat]
Official name wingless-type MMTV integration site family, member 16
Species Rat (Rattus norvegicus)
Entrez Gene ID 500047
Transcript(s) for this gene NM_001109223 (1662 bp), XM_001059648 (1704 bp), XM_575403 (1724 bp), XM_006236143 (1804 bp)
Official symbol Ptchd1 [Rat]
Official name patched domain containing 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 317517
Transcript(s) for this gene NM_001191734 (2676 bp), XM_001056385 (2676 bp), XM_228985 (2676 bp)
Official symbol Ctnnb1 [Rat]
Official name catenin (cadherin associated protein), beta 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 84353
Transcript(s) for this gene NM_053357 (2352 bp), XM_008766691 (3040 bp)
Official symbol Otx2 [Rat]
Official name orthodenticle homeobox 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 305858
Transcript(s) for this gene NM_001100566 (2339 bp), XM_001057814 (2086 bp), XM_001073859 (2265 bp), XM_224009 (2226 bp), XM_006251808 (3650 bp), XM_006251809 (3621 bp), XM_006251810 (2133 bp), XM_008770523 (3277 bp), XM_008770524 (2307 bp), XM_008770525 (3465 bp), XM_008770526 (2552 bp), XM_008770527 (2247 bp), XM_008770528 (3831 bp), XM_008770529 (3717 bp), XM_008770530 (2195 bp)
Official symbol Bmp8a [Rat]
Official name bone morphogenetic protein 8a
Species Rat (Rattus norvegicus)
Entrez Gene ID 680931
Transcript(s) for this gene NM_001109432 (1919 bp), XM_001059507 (2030 bp)
Official symbol Dhh [Rat]
Official name desert hedgehog
Species Rat (Rattus norvegicus)
Entrez Gene ID 84380
Transcript(s) for this gene NM_053367 (2479 bp), XM_001062733 (1486 bp), XM_343327 (1486 bp)
Official symbol Kctd11 [Rat]
Official name potassium channel tetramerization domain containing 11
Species Rat (Rattus norvegicus)
Entrez Gene ID 363634
Transcript(s) for this gene NM_001108831 (2164 bp), XM_001079650 (2164 bp), XM_343923 (2164 bp)
Official symbol Csnk1g1 [Rat]
Official name casein kinase 1, gamma 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 64086
Transcript(s) for this gene NM_022288 (1648 bp), XM_008766332 (2784 bp), XM_008766333 (2694 bp), XM_008766334 (1477 bp), XM_008766335 (2673 bp)
Official symbol Gsk3b [Rat]
Official name glycogen synthase kinase 3 beta
Species Rat (Rattus norvegicus)
Entrez Gene ID 84027
Transcript(s) for this gene NM_032080 (1525 bp), XM_006248373 (7585 bp), XM_006248374 (2239 bp), XM_006248375 (3092 bp), XM_008768745 (3786 bp)
Official symbol Cdon [Rat]
Official name cell adhesion associated, oncogene regulated
Species Rat (Rattus norvegicus)
Entrez Gene ID 50938
Transcript(s) for this gene NM_017358 (4573 bp), XM_006242791 (7211 bp), XM_006242792 (7800 bp), XM_006242793 (6857 bp), XM_008766066 (8610 bp)
Official symbol Csnk1d [Rat]
Official name casein kinase 1, delta
Species Rat (Rattus norvegicus)
Entrez Gene ID 64462
Transcript(s) for this gene NM_139060 (3646 bp), XM_008768511 (3695 bp)
Official symbol Bmp5 [Rat]
Official name bone morphogenetic protein 5
Species Rat (Rattus norvegicus)
Entrez Gene ID 315824
Transcript(s) for this gene NM_001108168 (3708 bp), XM_001059589 (2533 bp), XM_236415 (2017 bp)
Official symbol Csnk1e [Rat]
Official name casein kinase 1, epsilon
Species Rat (Rattus norvegicus)
Entrez Gene ID 58822
Transcript(s) for this gene NM_031617 (1251 bp), XM_006242038 (2693 bp)
Official symbol Wnt2b [Rat]
Official name wingless-type MMTV integration site family, member 2B
Species Rat (Rattus norvegicus)
Entrez Gene ID 116466
Transcript(s) for this gene NM_001191848 (1774 bp), XM_001066411 (1774 bp), XM_342308 (1774 bp)
Official symbol Smo [Rat]
Official name smoothened, frizzled class receptor
Species Rat (Rattus norvegicus)
Entrez Gene ID 25273
Transcript(s) for this gene NM_012807 (2382 bp)
Official symbol Prkacb [Rat]
Official name protein kinase, cAMP dependent, catalytic, beta
Species Rat (Rattus norvegicus)
Entrez Gene ID 293508
Transcript(s) for this gene NM_001077645 (1122 bp), XM_001059642 (1942 bp), XM_001077254 (1942 bp), XM_215070 (4617 bp), XM_006233451 (4949 bp), XM_006233452 (6454 bp), XM_006233453 (4696 bp)
Official symbol Csnk1a1 [Rat]
Official name casein kinase 1, alpha 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 113927
Transcript(s) for this gene NM_053615 (978 bp)
Official symbol Prkaca [Rat]
Official name protein kinase, cAMP-dependent, catalytic, alpha
Species Rat (Rattus norvegicus)
Entrez Gene ID 25636
Transcript(s) for this gene NM_001100922 (2253 bp), XM_001072411 (1565 bp), XM_341661 (1565 bp), XM_006255219 (2163 bp)
Official symbol Wnt4 [Rat]
Official name wingless-type MMTV integration site family, member 4
Species Rat (Rattus norvegicus)
Entrez Gene ID 84426
Transcript(s) for this gene NM_053402 (1211 bp)
Official symbol Wnt3a [Rat]
Official name wingless-type MMTV integration site family, member 3A
Species Rat (Rattus norvegicus)
Entrez Gene ID 303181
Transcript(s) for this gene NM_001107005 (2642 bp), XM_001076985 (1080 bp), XM_220546 (1275 bp), XM_003750837 (2651 bp), XM_003752424 (2642 bp), XM_006246487 (2803 bp)
Official symbol Gli3 [Rat]
Official name GLI family zinc finger 3
Species Rat (Rattus norvegicus)
Entrez Gene ID 140588
Transcript(s) for this gene NM_080405 (5027 bp), XM_001054276 (5027 bp), XM_225411 (5029 bp), XM_225413 (853 bp)
Official symbol Wnt1 [Rat]
Official name wingless-type MMTV integration site family, member 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 24881
Transcript(s) for this gene NM_001105714 (2360 bp), XM_001062385 (1439 bp), XM_235639 (1439 bp)
Official symbol Numb [Rat]
Official name numb homolog (Drosophila)
Species Rat (Rattus norvegicus)
Entrez Gene ID 29419
Transcript(s) for this gene NM_133287 (1779 bp), XM_234394 (1920 bp)
Official symbol Wnt8a [Rat]
Official name wingless-type MMTV integration site family, member 8A
Species Rat (Rattus norvegicus)
Entrez Gene ID 291678
Transcript(s) for this gene NM_001106155 (1692 bp), XM_001061171 (1080 bp), XM_226051 (1080 bp)
Official symbol Bmp7 [Rat]
Official name bone morphogenetic protein 7
Species Rat (Rattus norvegicus)
Entrez Gene ID 85272
Transcript(s) for this gene NM_001191856 (2448 bp), XM_001053727 (2210 bp), XM_342591 (2445 bp)
Official symbol Ihh [Rat]
Official name Indian hedgehog
Species Rat (Rattus norvegicus)
Entrez Gene ID 84399
Transcript(s) for this gene NM_053384 (2272 bp), XM_001060415 (2499 bp), XM_343590 (1284 bp), XM_576589 (2272 bp)
Official symbol Wnt2 [Rat]
Official name wingless-type MMTV integration site family member 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 114487
Transcript(s) for this gene XM_001059030 (2201 bp), XM_575397 (2201 bp)
Official symbol Wnt10a [Rat]
Official name wingless-type MMTV integration site family, member 10A
Species Rat (Rattus norvegicus)
Entrez Gene ID 316527
Transcript(s) for this gene NM_001108227 (2466 bp), XM_001059533 (1683 bp), XM_001059590 (2433 bp), XM_237296 (2278 bp)
Official symbol Shh [Rat]
Official name sonic hedgehog
Species Rat (Rattus norvegicus)
Entrez Gene ID 29499
Transcript(s) for this gene NM_017221 (1715 bp)
Official symbol Foxe1 [Rat]
Official name forkhead box E1
Species Rat (Rattus norvegicus)
Entrez Gene ID 192274
Transcript(s) for this gene NM_138909 (2807 bp)
Official symbol Wnt11 [Rat]
Official name wingless-type MMTV integration site family, member 11
Species Rat (Rattus norvegicus)
Entrez Gene ID 140584
Transcript(s) for this gene NM_080401 (2582 bp), XM_001065413 (2292 bp), XM_238122 (2202 bp), XM_006229718 (2429 bp), XM_006229719 (2878 bp), XM_006229720 (3800 bp), XM_008759667 (1962 bp)
Official symbol Wnt10b [Rat]
Official name wingless-type MMTV integration site family, member 10B
Species Rat (Rattus norvegicus)
Entrez Gene ID 315294
Transcript(s) for this gene NM_001108111 (2234 bp), XM_001062326 (2217 bp), XM_235636 (2217 bp)
Official symbol Bmp2 [Rat]
Official name bone morphogenetic protein 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 29373
Transcript(s) for this gene NM_017178 (1275 bp), XM_008762246 (3709 bp)
Official symbol Wnt7a [Rat]
Official name wingless-type MMTV integration site family, member 7A
Species Rat (Rattus norvegicus)
Entrez Gene ID 114850
Transcript(s) for this gene NM_001100473 (3150 bp), XM_001062984 (2111 bp), XM_001073352 (2111 bp), XM_001073379 (3150 bp), XM_342723 (3150 bp)
Official symbol Bmp4 [Rat]
Official name bone morphogenetic protein 4
Species Rat (Rattus norvegicus)
Entrez Gene ID 25296
Transcript(s) for this gene NM_012827 (1559 bp), XM_006251746 (2453 bp), XM_006251747 (2003 bp), XM_006251748 (1985 bp), XM_006251749 (1727 bp), XM_006251751 (1704 bp), XM_008770501 (1817 bp)
Official symbol Zic1 [Rat]
Official name Zic family member 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 64618
Transcript(s) for this gene NM_022677 (1344 bp), XM_008766454 (2756 bp)
Official symbol Wnt6 [Rat]
Official name wingless-type MMTV integration site family, member 6
Species Rat (Rattus norvegicus)
Entrez Gene ID 316526
Transcript(s) for this gene NM_001108226 (2063 bp), XM_001057298 (2056 bp), XM_237295 (2197 bp)
Official symbol Fgfr3 [Rat]
Official name fibroblast growth factor receptor 3
Species Rat (Rattus norvegicus)
Entrez Gene ID 84489
Transcript(s) for this gene NM_053429 (3187 bp), XM_006251390 (4231 bp), XM_006251392 (4228 bp), XM_006251393 (4225 bp), XM_006251394 (4225 bp), XM_006251395 (4222 bp), XM_006251396 (4218 bp)
Official symbol Fgf9 [Rat]
Official name fibroblast growth factor 9
Species Rat (Rattus norvegicus)
Entrez Gene ID 25444
Transcript(s) for this gene NM_012952 (1065 bp)
Official symbol FGFR3 [Human]
Official name fibroblast growth factor receptor 3
Species Human (Homo sapiens)
Entrez Gene ID 2261
Transcript(s) for this gene NM_000142 (4304 bp), NM_001163213 (4310 bp), NM_022965 (3968 bp), ENST00000474521, XM_006713868 (4315 bp), XM_006713869 (4312 bp), XM_006713870 (4312 bp), XM_006713871 (4309 bp), XM_006713872 (4303 bp), XM_006713873 (4303 bp), ENST00000260795, ENST00000340107, ENST00000352904, ENST00000412135, ENST00000440486, ENST00000481110, ENST00000613647
Official symbol MAPK1 [Human]
Official name mitogen-activated protein kinase 1
Species Human (Homo sapiens)
Entrez Gene ID 5594
Transcript(s) for this gene NM_002745 (5916 bp), NM_138957 (1514 bp), ENST00000491588, ENST00000215832, ENST00000398822, ENST00000544786
Official symbol FGF9 [Human]
Official name fibroblast growth factor 9
Species Human (Homo sapiens)
Entrez Gene ID 2254
Transcript(s) for this gene NM_002010 (4545 bp), ENST00000478546, ENST00000382353
Official symbol WNT6 [Human]
Official name wingless-type MMTV integration site family, member 6
Species Human (Homo sapiens)
Entrez Gene ID 7475
Transcript(s) for this gene NM_006522 (1700 bp), ENST00000486233, ENST00000233948
Official symbol GREM1 [Human]
Official name gremlin 1, DAN family BMP antagonist
Species Human (Homo sapiens)
Entrez Gene ID 26585
Transcript(s) for this gene NM_001191322 (3928 bp), NM_001191323 (4015 bp), NM_013372 (4150 bp), XM_005254301 (4164 bp), XM_006725542 (4164 bp), ENST00000560677, ENST00000560830, ENST00000622074
Official symbol HHAT [Human]
Official name hedgehog acyltransferase
Species Human (Homo sapiens)
Entrez Gene ID 55733
Transcript(s) for this gene NM_001122834 (3575 bp), NM_001170564 (3164 bp), NM_001170580 (3630 bp), NM_001170587 (3507 bp), NM_001170588 (3446 bp), NM_018194 (3641 bp), XM_006711441 (3702 bp), ENST00000261458, ENST00000367009, ENST00000367010, ENST00000413764, ENST00000537898, ENST00000541565, ENST00000545154, ENST00000545781
Official symbol ZIC1 [Human]
Official name Zic family member 1
Species Human (Homo sapiens)
Entrez Gene ID 7545
Transcript(s) for this gene NM_003412 (5231 bp), ENST00000481840, ENST00000282928
Official symbol WNT7A [Human]
Official name wingless-type MMTV integration site family, member 7A
Species Human (Homo sapiens)
Entrez Gene ID 7476
Transcript(s) for this gene NM_004625 (1732 bp), ENST00000497808, ENST00000285018
Official symbol BMP4 [Human]
Official name bone morphogenetic protein 4
Species Human (Homo sapiens)
Entrez Gene ID 652
Transcript(s) for this gene NM_001202 (1957 bp), NM_130850 (1748 bp), NM_130851 (1802 bp), ENST00000558489, XM_005268015 (1741 bp), ENST00000245451, ENST00000417573, ENST00000558984, ENST00000559087
Official symbol BMP2 [Human]
Official name bone morphogenetic protein 2
Species Human (Homo sapiens)
Entrez Gene ID 650
Transcript(s) for this gene NM_001200 (3150 bp), ENST00000378827
Official symbol WNT10B [Human]
Official name wingless-type MMTV integration site family, member 10B
Species Human (Homo sapiens)
Entrez Gene ID 7480
Transcript(s) for this gene NM_003394 (2370 bp), ENST00000475740, ENST00000301061, ENST00000403957, ENST00000407467
Official symbol WNT11 [Human]
Official name wingless-type MMTV integration site family, member 11
Species Human (Homo sapiens)
Entrez Gene ID 7481
Transcript(s) for this gene NM_004626 (1927 bp), ENST00000532150, XM_005274231 (2113 bp), ENST00000322563, ENST00000621122
Official symbol SHH [Human]
Official name sonic hedgehog
Species Human (Homo sapiens)
Entrez Gene ID 6469
Transcript(s) for this gene NM_000193 (1576 bp), ENST00000472308, ENST00000297261
Official symbol WNT10A [Human]
Official name wingless-type MMTV integration site family, member 10A
Species Human (Homo sapiens)
Entrez Gene ID 80326
Transcript(s) for this gene NM_025216 (2375 bp), ENST00000489887, ENST00000258411
Official symbol WNT2 [Human]
Official name wingless-type MMTV integration site family member 2
Species Human (Homo sapiens)
Entrez Gene ID 7472
Transcript(s) for this gene NM_003391 (2907 bp), NR_024047 (2843 bp), XM_006716109 (2563 bp), ENST00000265441
Official symbol NUMB [Human]
Official name numb homolog (Drosophila)
Species Human (Homo sapiens)
Entrez Gene ID 8650
Transcript(s) for this gene NM_001005743 (3647 bp), NM_001005744 (3503 bp), NM_001005745 (3470 bp), NM_003744 (3614 bp), ENST00000557774, XM_005268142 (3566 bp), XM_005268143 (3365 bp), XM_005268144 (3528 bp), XM_005268145 (3519 bp), XM_005268146 (3422 bp), XM_006720283 (3499 bp), XM_006720284 (3557 bp), XM_006720285 (3288 bp), XM_006720286 (3413 bp), XM_006720287 (3384 bp), XM_006720288 (3272 bp), XM_006720289 (3128 bp), XM_006720290 (2991 bp), XM_006720291 (3090 bp), XM_006720292 (2958 bp), XM_006720293 (2981 bp), XM_006720294 (2844 bp), XM_006720295 (2943 bp), XM_006720296 (2811 bp), ENST00000355058, ENST00000356296, ENST00000359560, ENST00000535282, ENST00000544991, ENST00000554521, ENST00000554546, ENST00000555238, ENST00000555394, ENST00000555738, ENST00000556772, ENST00000557597, ENST00000559312, ENST00000560335
Official symbol IHH [Human]
Official name indian hedgehog
Species Human (Homo sapiens)
Entrez Gene ID 3549
Transcript(s) for this gene NM_002181 (2074 bp), ENST00000295731
Official symbol BMP7 [Human]
Official name bone morphogenetic protein 7
Species Human (Homo sapiens)
Entrez Gene ID 655
Transcript(s) for this gene NM_001719 (4049 bp), ENST00000530870, ENST00000395863, ENST00000395864, ENST00000450594
Official symbol WNT8A [Human]
Official name wingless-type MMTV integration site family, member 8A
Species Human (Homo sapiens)
Entrez Gene ID 7478
Transcript(s) for this gene NM_031933 (1597 bp), NM_058244 (1722 bp), NM_001300938 (1398 bp), NM_001300939 (1814 bp), XM_005272076 (1543 bp), XM_005272077 (1880 bp), ENST00000398754, ENST00000506684
Official symbol WNT1 [Human]
Official name wingless-type MMTV integration site family, member 1
Species Human (Homo sapiens)
Entrez Gene ID 7471
Transcript(s) for this gene NM_005430 (2284 bp), ENST00000293549, ENST00000613114
Official symbol GLI3 [Human]
Official name GLI family zinc finger 3
Species Human (Homo sapiens)
Entrez Gene ID 2737
Transcript(s) for this gene NM_000168 (8228 bp), ENST00000479210, XM_005249703 (8253 bp), XM_005249704 (8442 bp), ENST00000395925, ENST00000437480, XM_011515272 (8232 bp), XM_011515273 (8285 bp), XM_011515274 (8101 bp)
Official symbol WNT4 [Human]
Official name wingless-type MMTV integration site family, member 4
Species Human (Homo sapiens)
Entrez Gene ID 54361
Transcript(s) for this gene NM_030761 (3905 bp), XM_005245897 (3809 bp), ENST00000290167
Official symbol WNT3A [Human]
Official name wingless-type MMTV integration site family, member 3A
Species Human (Homo sapiens)
Entrez Gene ID 89780
Transcript(s) for this gene NM_033131 (2988 bp), ENST00000284523
Official symbol LRP2 [Human]
Official name LDL receptor related protein 2
Species Human (Homo sapiens)
Entrez Gene ID 4036
Transcript(s) for this gene NM_004525 (15735 bp), ENST00000493501, XM_006712526 (15751 bp), XM_006712527 (13306 bp), XM_006712528 (10205 bp), ENST00000263816, ENST00000443831, XM_011511183 (15607 bp), XM_011511184 (13248 bp), XM_011511185 (10146 bp)
Official symbol NPC1 [Human]
Official name Niemann-Pick disease, type C1
Species Human (Homo sapiens)
Entrez Gene ID 4864
Transcript(s) for this gene NM_000271 (4827 bp), ENST00000591955, XM_005258277 (4427 bp), XM_005258278 (4755 bp), XM_005258279 (4376 bp), XM_006722479 (5752 bp), ENST00000269228
Official symbol PRKACA [Human]
Official name protein kinase, cAMP-dependent, catalytic, alpha
Species Human (Homo sapiens)
Entrez Gene ID 5566
Transcript(s) for this gene NM_002730 (2689 bp), NM_207518 (2490 bp), ENST00000588209, XM_005259984 (3114 bp), ENST00000308677, ENST00000589994, ENST00000590853
Official symbol PRKACG [Human]
Official name protein kinase cAMP-activated catalytic subunit gamma
Species Human (Homo sapiens)
Entrez Gene ID 5568
Transcript(s) for this gene NM_002732 (1614 bp), ENST00000377276
Official symbol CSNK1A1L [Human]
Official name casein kinase 1, alpha 1-like
Species Human (Homo sapiens)
Entrez Gene ID 122011
Transcript(s) for this gene NM_145203 (2405 bp), ENST00000379800
Official symbol SMO [Human]
Official name smoothened, frizzled class receptor
Species Human (Homo sapiens)
Entrez Gene ID 6608
Transcript(s) for this gene NM_005631 (3772 bp), ENST00000495998, ENST00000249373
Official symbol PRKACB [Human]
Official name protein kinase, cAMP-dependent, catalytic, beta
Species Human (Homo sapiens)
Entrez Gene ID 5567
Transcript(s) for this gene NM_001242857 (4515 bp), NM_001242858 (4458 bp), NM_001242859 (4506 bp), NM_001242860 (4650 bp), NM_001242861 (4542 bp), NM_001242862 (4254 bp), NM_002731 (4616 bp), NM_182948 (4520 bp), NM_207578 (2119 bp), ENST00000470673, NM_001300915 (2156 bp), NM_001300916 (2023 bp), NM_001300917 (1961 bp), XM_005271015 (4349 bp), XM_005271016 (4576 bp), XM_005271017 (4340 bp), XM_005271018 (4539 bp), XM_005271019 (4517 bp), XM_005271020 (1819 bp), XM_006710758 (4590 bp), ENST00000370680, ENST00000370682, ENST00000370684, ENST00000370685, ENST00000370688, ENST00000370689, ENST00000394838, ENST00000394839, ENST00000446538, ENST00000610457, ENST00000610703, ENST00000614872
Official symbol WNT2B [Human]
Official name wingless-type MMTV integration site family, member 2B
Species Human (Homo sapiens)
Entrez Gene ID 7482
Transcript(s) for this gene NM_004185 (2925 bp), NM_024494 (2515 bp), ENST00000478360, NM_001291880 (2854 bp), ENST00000256640, ENST00000369684, ENST00000369686
Official symbol GAS1 [Human]
Official name growth arrest specific 1
Species Human (Homo sapiens)
Entrez Gene ID 2619
Transcript(s) for this gene NM_002048 (2844 bp), ENST00000298743
Official symbol CSNK1E [Human]
Official name casein kinase 1, epsilon
Species Human (Homo sapiens)
Entrez Gene ID 1454
Transcript(s) for this gene NM_001894 (2670 bp), NM_152221 (2820 bp), ENST00000498529, ENST00000359867, ENST00000396832, ENST00000400206, ENST00000403904, ENST00000405675, ENST00000413574
Official symbol BMP5 [Human]
Official name bone morphogenetic protein 5
Species Human (Homo sapiens)
Entrez Gene ID 653
Transcript(s) for this gene NM_021073 (2207 bp), XM_005249304 (1840 bp), ENST00000370830
Official symbol CDON [Human]
Official name cell adhesion associated, oncogene regulated
Species Human (Homo sapiens)
Entrez Gene ID 50937
Transcript(s) for this gene NM_001243597 (8116 bp), NM_016952 (8051 bp), XM_001133286 (5512 bp), XM_001133299 (4514 bp), ENST00000525625, ENST00000263577, ENST00000392693, ENST00000531738, XM_011542862 (7651 bp), XM_011542863 (7611 bp), XM_011542864 (7510 bp), XM_011542865 (7451 bp), XM_011542866 (8205 bp)
Official symbol FBXW11 [Human]
Official name F-box and WD repeat domain containing 11
Species Human (Homo sapiens)
Entrez Gene ID 23291
Transcript(s) for this gene NM_012300 (4575 bp), NM_033644 (4536 bp), NM_033645 (4473 bp), ENST00000522891, XM_005265855 (4411 bp), XM_005265856 (4574 bp), XM_005265857 (4136 bp), XM_005265858 (4473 bp), XM_005265859 (4065 bp), ENST00000265094, ENST00000296933, ENST00000393802, XM_011534492 (4452 bp)
Official symbol GSK3B [Human]
Official name glycogen synthase kinase 3 beta
Species Human (Homo sapiens)
Entrez Gene ID 2932
Transcript(s) for this gene NM_001146156 (7095 bp), NM_002093 (7134 bp), ENST00000474830, XM_006713610 (7128 bp), XM_006713611 (7089 bp), ENST00000264235, ENST00000316626
Official symbol CSNK1G1 [Human]
Official name casein kinase 1 gamma 1
Species Human (Homo sapiens)
Entrez Gene ID 53944
Transcript(s) for this gene NM_001011664 (8089 bp), NM_022048 (8163 bp), ENST00000303052, ENST00000607537
Official symbol KCTD11 [Human]
Official name potassium channel tetramerization domain containing 11
Species Human (Homo sapiens)
Entrez Gene ID 147040
Transcript(s) for this gene NM_001002914 (3081 bp), ENST00000576980, ENST00000333751
Official symbol CSNK1A1 [Human]
Official name casein kinase 1, alpha 1
Species Human (Homo sapiens)
Entrez Gene ID 1452
Transcript(s) for this gene NM_001025105 (2661 bp), NM_001892 (2577 bp), NM_001271741 (2541 bp), NM_001271742 (2100 bp), ENST00000499521, ENST00000261798, ENST00000377843, ENST00000412431, ENST00000504676, ENST00000515435, ENST00000515748, ENST00000515768, ENST00000606299, ENST00000606719
Official symbol PTCHD1 [Human]
Official name patched domain containing 1
Species Human (Homo sapiens)
Entrez Gene ID 139411
Transcript(s) for this gene NM_173495 (5305 bp), ENST00000379361, ENST00000616022
Official symbol PTCHD3 [Human]
Official name patched domain containing 3
Species Human (Homo sapiens)
Entrez Gene ID 374308
Transcript(s) for this gene NM_001034842 (2528 bp), XM_370541 (2529 bp), XM_005252449 (1248 bp), XM_005276863 (1248 bp), ENST00000438700, ENST00000622555
Official symbol OTX2 [Human]
Official name orthodenticle homeobox 2
Species Human (Homo sapiens)
Entrez Gene ID 5015
Transcript(s) for this gene NM_021728 (2219 bp), NM_172337 (2118 bp), NM_001270523 (2195 bp), NM_001270524 (2348 bp), NM_001270525 (2142 bp), ENST00000339475, ENST00000408990, ENST00000554559, ENST00000554788, ENST00000555006, NR_073034 (0 bp), NR_073036 (0 bp)
Official symbol CSNK1D [Human]
Official name casein kinase 1, delta
Species Human (Homo sapiens)
Entrez Gene ID 1453
Transcript(s) for this gene NM_001893 (3714 bp), NM_139062 (3778 bp), XM_001132734 (3468 bp), ENST00000584913, XM_005256336 (3952 bp), XM_005256337 (1911 bp), XR_243518 (3983 bp), ENST00000314028, ENST00000392334, ENST00000398519
Official symbol BMP8B [Human]
Official name bone morphogenetic protein 8b
Species Human (Homo sapiens)
Entrez Gene ID 656
Transcript(s) for this gene NM_001720 (3773 bp), XM_005271149 (908 bp), ENST00000372827, ENST00000397360
Official symbol BMP6 [Human]
Official name bone morphogenetic protein 6
Species Human (Homo sapiens)
Entrez Gene ID 654
Transcript(s) for this gene NM_001718 (3105 bp), ENST00000283147
Official symbol BMP8A [Human]
Official name bone morphogenetic protein 8a
Species Human (Homo sapiens)
Entrez Gene ID 353500
Transcript(s) for this gene NM_181809 (5642 bp), XM_006710616 (1216 bp), ENST00000331593, XM_011541381 (1887 bp), XM_011541382 (1884 bp)
Official symbol NPC1L1 [Human]
Official name NPC1-like 1
Species Human (Homo sapiens)
Entrez Gene ID 29881
Transcript(s) for this gene NM_001101648 (4985 bp), NM_013389 (5066 bp), NM_001300967 (2571 bp), ENST00000289547, ENST00000381160, ENST00000423141, ENST00000546276
Official symbol WNT16 [Human]
Official name wingless-type MMTV integration site family, member 16
Species Human (Homo sapiens)
Entrez Gene ID 51384
Transcript(s) for this gene NM_016087 (2894 bp), NM_057168 (3132 bp), ENST00000222462, ENST00000361301
Official symbol CTNNB1 [Human]
Official name catenin (cadherin-associated protein), beta 1, 88kDa
Species Human (Homo sapiens)
Entrez Gene ID 1499
Transcript(s) for this gene NM_001098209 (3415 bp), NM_001098210 (3256 bp), NM_001904 (3720 bp), XM_001133660 (3297 bp), XM_001133664 (2756 bp), XM_001133673 (3134 bp), XM_001133675 (4137 bp), ENST00000488914, XM_005264886 (3731 bp), XM_006712983 (3629 bp), XM_006712984 (3324 bp), XM_006712985 (3104 bp), ENST00000349496, ENST00000396183, ENST00000396185, ENST00000405570, ENST00000453024
Official symbol BTRC [Human]
Official name beta-transducin repeat containing E3 ubiquitin protein ligase
Species Human (Homo sapiens)
Entrez Gene ID 8945
Transcript(s) for this gene NM_001256856 (6102 bp), NM_003939 (6072 bp), NM_033637 (6180 bp), ENST00000493877, XM_005270264 (5454 bp), XM_006718054 (6464 bp), ENST00000370187, ENST00000393441, ENST00000408038
Official symbol CSNK1G2 [Human]
Official name casein kinase 1 gamma 2
Species Human (Homo sapiens)
Entrez Gene ID 1455
Transcript(s) for this gene NM_001319 (2921 bp), ENST00000591002, XM_005259498 (3008 bp), XM_005259499 (2828 bp), XM_005259500 (2993 bp), XM_005259501 (3367 bp), XM_005259502 (3654 bp), ENST00000255641
Official symbol IFT52 [Human]
Official name intraflagellar transport 52
Species Human (Homo sapiens)
Entrez Gene ID 51098
Transcript(s) for this gene NM_016004 (1675 bp), ENST00000486243, XM_005260417 (1660 bp), ENST00000373030, ENST00000373039
Official symbol WIF1 [Human]
Official name WNT inhibitory factor 1
Species Human (Homo sapiens)
Entrez Gene ID 11197
Transcript(s) for this gene NM_007191 (2240 bp), ENST00000286574
Official symbol WNT8B [Human]
Official name wingless-type MMTV integration site family, member 8B
Species Human (Homo sapiens)
Entrez Gene ID 7479
Transcript(s) for this gene NM_003393 (1996 bp), ENST00000343737
Official symbol SUFU [Human]
Official name suppressor of fused homolog (Drosophila)
Species Human (Homo sapiens)
Entrez Gene ID 51684
Transcript(s) for this gene NM_001178133 (1900 bp), NM_016169 (4994 bp), ENST00000471000, XM_006717892 (4456 bp), ENST00000369899, ENST00000369902, ENST00000423559
Official symbol WNT3 [Human]
Official name wingless-type MMTV integration site family, member 3
Species Human (Homo sapiens)
Entrez Gene ID 7473
Transcript(s) for this gene NM_030753 (3385 bp), ENST00000576471, ENST00000225512
Official symbol FKBP8 [Human]
Official name FK506 binding protein 8, 38kDa
Species Human (Homo sapiens)
Entrez Gene ID 23770
Transcript(s) for this gene NM_012181 (1787 bp), ENST00000596494, XM_005259841 (1779 bp), XM_005259842 (1776 bp), XM_005259844 (1798 bp), ENST00000222308, ENST00000596558, ENST00000597960, ENST00000608443
Official symbol RAB23 [Human]
Official name RAB23, member RAS oncogene family
Species Human (Homo sapiens)
Entrez Gene ID 51715
Transcript(s) for this gene NM_016277 (4837 bp), NM_183227 (4391 bp), NM_001278666 (4368 bp), NM_001278667 (4540 bp), NM_001278668 (4367 bp), XM_005249179 (1131 bp), ENST00000317483, ENST00000468148
Official symbol MTSS1 [Human]
Official name metastasis suppressor 1
Species Human (Homo sapiens)
Entrez Gene ID 9788
Transcript(s) for this gene NM_014751 (5054 bp), ENST00000529463, NM_001282971 (5066 bp), NM_001282974 (4979 bp), XM_005251111 (5333 bp), XM_005251113 (5138 bp), XM_005251118 (4811 bp), XM_006716700 (5330 bp), XM_006716701 (5321 bp), XM_006716702 (5282 bp), XM_006716703 (5087 bp), XM_006716704 (5003 bp), XM_006716705 (4955 bp), XM_006716706 (4760 bp), XM_006716707 (2516 bp), ENST00000325064, ENST00000378017, ENST00000431961, ENST00000518547, ENST00000524090, XM_011517403 (4787 bp), XM_011517404 (4919 bp), XM_011517405 (5630 bp), XM_011517406 (5627 bp), XM_011517407 (3987 bp), XM_011517408 (5057 bp)
Official symbol WNT9A [Human]
Official name wingless-type MMTV integration site family, member 9A
Species Human (Homo sapiens)
Entrez Gene ID 7483
Transcript(s) for this gene NM_003395 (1240 bp), ENST00000272164
Official symbol WNT9B [Human]
Official name wingless-type MMTV integration site family, member 9B
Species Human (Homo sapiens)
Entrez Gene ID 7484
Transcript(s) for this gene NM_003396 (1464 bp), XM_005257637 (2654 bp), XM_006725631 (2654 bp), ENST00000290015, ENST00000393461
Official symbol HHIP [Human]
Official name hedgehog interacting protein
Species Human (Homo sapiens)
Entrez Gene ID 64399
Transcript(s) for this gene NM_022475 (3555 bp), ENST00000515080, XM_005263178 (5235 bp), XM_006714288 (5231 bp), ENST00000296575, ENST00000434550
Official symbol PTCH1 [Human]
Official name patched 1
Species Human (Homo sapiens)
Entrez Gene ID 5727
Transcript(s) for this gene NM_000264 (7957 bp), NM_001083602 (8065 bp), NM_001083603 (7911 bp), NM_001083604 (7675 bp), NM_001083605 (7658 bp), NM_001083606 (7757 bp), NM_001083607 (7831 bp), ENST00000553256, XM_005252102 (7072 bp), XR_242599 (7617 bp), ENST00000331920, ENST00000375274, ENST00000418258, ENST00000421141, ENST00000429896, ENST00000430669, ENST00000437951, ENST00000468211
Official symbol GLI2 [Human]
Official name GLI family zinc finger 2
Species Human (Homo sapiens)
Entrez Gene ID 2736
Transcript(s) for this gene NM_005270 (6780 bp), NM_030379 (4862 bp), NM_030380 (4811 bp), NM_030381 (3631 bp), ENST00000482119, ENST00000472722, XM_006712422 (6564 bp), XM_006712423 (6425 bp), ENST00000314490, ENST00000361492, ENST00000452319
Official symbol DISP3 [Human]
Official name dispatched RND transporter family member 3
Species Human (Homo sapiens)
Entrez Gene ID 57540
Transcript(s) for this gene NM_020780 (5231 bp), XM_052561 (5655 bp), XM_938154 (5658 bp), ENST00000423056, ENST00000294484, ENST00000304391, XM_011541828 (5101 bp), XM_011541829 (4189 bp), XM_011541830 (3103 bp), XM_011541831 (2927 bp), XM_011541832 (2757 bp), XM_011541833 (2719 bp), XM_011541834 (2705 bp), XM_011541835 (2548 bp)
Official symbol CEP76 [Human]
Official name centrosomal protein 76kDa
Species Human (Homo sapiens)
Entrez Gene ID 79959
Transcript(s) for this gene NM_024899 (2947 bp), NM_001271989 (2722 bp), XM_005258149 (2549 bp), XM_005258150 (2527 bp), XM_006722356 (2428 bp), XM_006722357 (2395 bp), ENST00000262127, ENST00000423709
Official symbol WNT5A [Human]
Official name wingless-type MMTV integration site family, member 5A
Species Human (Homo sapiens)
Entrez Gene ID 7474
Transcript(s) for this gene NM_001256105 (5599 bp), NM_003392 (6194 bp), ENST00000497817, XM_006713324 (5537 bp), ENST00000264634, ENST00000474267, ENST00000497027, ENST00000614415
Official symbol SFRP1 [Human]
Official name secreted frizzled-related protein 1
Species Human (Homo sapiens)
Entrez Gene ID 6422
Transcript(s) for this gene NM_003012 (4482 bp), ENST00000220772, ENST00000379845
Official symbol PRKX [Human]
Official name protein kinase, X-linked
Species Human (Homo sapiens)
Entrez Gene ID 5613
Transcript(s) for this gene NM_005044 (6084 bp), ENST00000496648, XM_005274560 (2946 bp), XM_005274561 (5937 bp), ENST00000262848
Official symbol PTCH2 [Human]
Official name patched 2
Species Human (Homo sapiens)
Entrez Gene ID 8643
Transcript(s) for this gene NM_001166292 (4298 bp), NM_003738 (3773 bp), ENST00000372192, ENST00000447098
Official symbol STK36 [Human]
Official name serine/threonine kinase 36
Species Human (Homo sapiens)
Entrez Gene ID 27148
Transcript(s) for this gene NM_001243313 (4883 bp), NM_015690 (4946 bp), ENST00000492486, ENST00000480709, XM_005246464 (4823 bp), XM_006712420 (4796 bp), XM_006712421 (3120 bp), ENST00000295709, ENST00000392105, ENST00000440309
Official symbol WNT7B [Human]
Official name wingless-type MMTV integration site family, member 7B
Species Human (Homo sapiens)
Entrez Gene ID 7477
Transcript(s) for this gene NM_058238 (3928 bp), XM_001718758 (1986 bp), ENST00000339464, ENST00000409496, ENST00000410058, ENST00000410089
Official symbol ERBB4 [Human]
Official name v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Species Human (Homo sapiens)
Entrez Gene ID 2066
Transcript(s) for this gene NM_001042599 (11893 bp), NM_005235 (11941 bp), ENST00000484594, XM_005246375 (12447 bp), XM_005246376 (12420 bp), XM_005246377 (12372 bp), XM_006712364 (12495 bp), ENST00000342788, ENST00000402597, ENST00000436443
Official symbol WNT5B [Human]
Official name wingless-type MMTV integration site family, member 5B
Species Human (Homo sapiens)
Entrez Gene ID 81029
Transcript(s) for this gene NM_030775 (2184 bp), NM_032642 (2251 bp), ENST00000545747, XM_005253792 (2204 bp), XM_006719019 (2170 bp), ENST00000310594, ENST00000397196, ENST00000537031, ENST00000542408
Official symbol FOXE1 [Human]
Official name forkhead box E1 (thyroid transcription factor 2)
Species Human (Homo sapiens)
Entrez Gene ID 2304
Transcript(s) for this gene NM_004473 (3473 bp), ENST00000375123
Official symbol SIAH1 [Human]
Official name siah E3 ubiquitin protein ligase 1
Species Human (Homo sapiens)
Entrez Gene ID 6477
Transcript(s) for this gene NM_001006610 (2393 bp), NM_001006611 (2095 bp), NM_003031 (2003 bp), ENST00000573005, XM_006721246 (2191 bp), ENST00000356721, ENST00000380006, ENST00000394725
Official symbol PRKY [Human]
Official name protein kinase, Y-linked, pseudogene
Species Human (Homo sapiens)
Entrez Gene ID 5616
Transcript(s) for this gene NM_002760 (7216 bp), NR_028062 (7240 bp), ENST00000528056, ENST00000533551
Official symbol PTCHD4 [Human]
Official name patched domain containing 4
Species Human (Homo sapiens)
Entrez Gene ID 442213
Transcript(s) for this gene NM_001013732 (2850 bp), NM_207499 (3268 bp), XM_498096 (1656 bp), XM_006715099 (3408 bp), ENST00000339488
Official symbol ZIC2 [Human]
Official name Zic family member 2
Species Human (Homo sapiens)
Entrez Gene ID 7546
Transcript(s) for this gene NM_007129 (2991 bp), ENST00000490085, ENST00000376335, ENST00000620342
Official symbol CRIM1 [Human]
Official name cysteine rich transmembrane BMP regulator 1 (chordin-like)
Species Human (Homo sapiens)
Entrez Gene ID 51232
Transcript(s) for this gene NM_016441 (5628 bp), ENST00000497236, ENST00000473403, XM_005264357 (5430 bp), XM_005264358 (5409 bp), ENST00000280527
Official symbol DHH [Human]
Official name desert hedgehog
Species Human (Homo sapiens)
Entrez Gene ID 50846
Transcript(s) for this gene NM_021044 (1971 bp), ENST00000266991
Official symbol C18orf8 [Human]
Official name chromosome 18 open reading frame 8
Species Human (Homo sapiens)
Entrez Gene ID 29919
Transcript(s) for this gene NM_013326 (2226 bp), NM_001276342 (1958 bp), XM_006722445 (2051 bp), ENST00000269221, ENST00000590868, ENST00000615148, NR_075075 (0 bp), NR_075076 (0 bp)
Official symbol GLI1 [Human]
Official name GLI family zinc finger 1
Species Human (Homo sapiens)
Entrez Gene ID 2735
Transcript(s) for this gene NM_001160045 (3414 bp), NM_001167609 (3483 bp), NM_005269 (3618 bp), ENST00000530789, XM_005268799 (3481 bp), XM_011538189 (3703 bp), XM_011538190 (3388 bp), ENST00000228682, ENST00000543426, ENST00000546141
Official symbol Mapk1 [Mouse]
Official name mitogen-activated protein kinase 1
Species Mouse (Mus musculus)
Entrez Gene ID 26413
Transcript(s) for this gene NM_001038663 (1932 bp), NM_011949 (5099 bp), ENSMUST00000145409, XM_006522147 (2926 bp)
Official symbol Fgf9 [Mouse]
Official name fibroblast growth factor 9
Species Mouse (Mus musculus)
Entrez Gene ID 14180
Transcript(s) for this gene NM_013518 (4145 bp), XM_006518553 (3502 bp), XM_006518554 (3548 bp)
Official symbol Fgfr3 [Mouse]
Official name fibroblast growth factor receptor 3
Species Mouse (Mus musculus)
Entrez Gene ID 14184
Transcript(s) for this gene NM_001163215 (4245 bp), NM_001163216 (3960 bp), NM_001163217 (4020 bp), NM_001205270 (4222 bp), NM_008010 (4219 bp), ENSMUST00000181298, XM_006503713 (4614 bp), XM_006503714 (4611 bp), XM_006503715 (4606 bp), XM_006503716 (4607 bp), XM_006503717 (4603 bp), XM_006503718 (4600 bp), XM_006503719 (4598 bp), XM_006503720 (4590 bp), XM_006503721 (4591 bp), XM_006503722 (4583 bp), XM_006503723 (4560 bp), XM_006503724 (4536 bp), XM_006503725 (4237 bp), XM_006503726 (4237 bp), XM_006503727 (4222 bp), XM_006503728 (4216 bp), XM_006503729 (4157 bp), XM_006503730 (4183 bp), XM_006503731 (4125 bp), XM_006503732 (4037 bp)
Official symbol Wnt6 [Mouse]
Official name wingless-type MMTV integration site family, member 6
Species Mouse (Mus musculus)
Entrez Gene ID 22420
Transcript(s) for this gene NM_009526 (2068 bp), XM_006495887 (2185 bp), XM_006495888 (2180 bp), XM_006495889 (2178 bp)
Official symbol Grem1 [Mouse]
Official name gremlin 1
Species Mouse (Mus musculus)
Entrez Gene ID 23892
Transcript(s) for this gene NM_011824 (1639 bp), XM_006499444 (1778 bp)
Official symbol Zic1 [Mouse]
Official name zinc finger protein of the cerebellum 1
Species Mouse (Mus musculus)
Entrez Gene ID 22771
Transcript(s) for this gene NM_009573 (3350 bp), XM_973507 (2228 bp), XM_006511061 (5269 bp)
Official symbol Hhat [Mouse]
Official name hedgehog acyltransferase
Species Mouse (Mus musculus)
Entrez Gene ID 226861
Transcript(s) for this gene NM_144881 (2835 bp), ENSMUST00000123721, XM_006497251 (2891 bp), XM_006497252 (1939 bp)
Official symbol Bmp4 [Mouse]
Official name bone morphogenetic protein 4
Species Mouse (Mus musculus)
Entrez Gene ID 12159
Transcript(s) for this gene NM_007554 (2059 bp), ENSMUST00000135408, XM_006518467 (1843 bp), XM_006518468 (1902 bp), NM_001316360 (1934 bp), XM_011244934 (1736 bp), XM_011244935 (1699 bp)
Official symbol Wnt7a [Mouse]
Official name wingless-type MMTV integration site family, member 7A
Species Mouse (Mus musculus)
Entrez Gene ID 22421
Transcript(s) for this gene NM_009527 (3176 bp), ENSMUST00000133092
Official symbol Bmp2 [Mouse]
Official name bone morphogenetic protein 2
Species Mouse (Mus musculus)
Entrez Gene ID 12156
Transcript(s) for this gene NM_007553 (3566 bp), XM_006498619 (3133 bp)
Official symbol Wnt10b [Mouse]
Official name wingless-type MMTV integration site family, member 10B
Species Mouse (Mus musculus)
Entrez Gene ID 22410
Transcript(s) for this gene NM_011718 (2272 bp), XM_006520891 (3053 bp), XM_006520892 (3040 bp), XM_006520893 (2779 bp)
Official symbol Wnt11 [Mouse]
Official name wingless-type MMTV integration site family, member 11
Species Mouse (Mus musculus)
Entrez Gene ID 22411
Transcript(s) for this gene NM_009519 (2788 bp), NM_001285792 (3022 bp), NM_001285794 (2780 bp), NM_001285795 (2624 bp), XM_006507586 (3034 bp), XM_006507587 (2885 bp), XM_011241733 (1494 bp)
Official symbol Foxe1 [Mouse]
Official name forkhead box E1
Species Mouse (Mus musculus)
Entrez Gene ID 110805
Transcript(s) for this gene NM_183298 (1116 bp), XM_975742 (1332 bp)
Official symbol Shh [Mouse]
Official name sonic hedgehog
Species Mouse (Mus musculus)
Entrez Gene ID 20423
Transcript(s) for this gene NM_009170 (2727 bp), XM_006535648 (2158 bp), XM_006535649 (2943 bp)
Official symbol Wnt10a [Mouse]
Official name wingless-type MMTV integration site family, member 10A
Species Mouse (Mus musculus)
Entrez Gene ID 22409
Transcript(s) for this gene NM_009518 (1977 bp)
Official symbol Wnt2 [Mouse]
Official name wingless-type MMTV integration site family, member 2
Species Mouse (Mus musculus)
Entrez Gene ID 22413
Transcript(s) for this gene NM_023653 (2115 bp), XM_622566 (912 bp), XM_006505045 (5465 bp)
Official symbol Bmp7 [Mouse]
Official name bone morphogenetic protein 7
Species Mouse (Mus musculus)
Entrez Gene ID 12162
Transcript(s) for this gene NM_007557 (3670 bp), ENSMUST00000137247
Official symbol Ihh [Mouse]
Official name Indian hedgehog
Species Mouse (Mus musculus)
Entrez Gene ID 16147
Transcript(s) for this gene NM_010544 (2464 bp)
Official symbol Numb [Mouse]
Official name numb homolog (Drosophila)
Species Mouse (Mus musculus)
Entrez Gene ID 18222
Transcript(s) for this gene NM_001136075 (3382 bp), NM_010949 (3235 bp), NM_001272055 (3349 bp), NM_001272056 (3432 bp), XM_006515572 (3627 bp), XM_006515573 (3593 bp), XM_006515574 (3479 bp), XM_006515575 (3446 bp), XM_006515576 (3727 bp), XM_006515577 (3678 bp), XM_006515578 (3694 bp), XM_011244012 (3763 bp), NR_073563 (0 bp), NR_073564 (0 bp)
Official symbol Wnt8a [Mouse]
Official name wingless-type MMTV integration site family, member 8A
Species Mouse (Mus musculus)
Entrez Gene ID 20890
Transcript(s) for this gene NM_009290 (1519 bp), XM_006525738 (2592 bp), XM_011246866 (2226 bp)
Official symbol Gli3 [Mouse]
Official name GLI-Kruppel family member GLI3
Species Mouse (Mus musculus)
Entrez Gene ID 14634
Transcript(s) for this gene NM_008130 (8428 bp), ENSMUST00000141194, XM_006516552 (8720 bp), XM_006516553 (7930 bp), XM_006516554 (7926 bp)
Official symbol Wnt1 [Mouse]
Official name wingless-type MMTV integration site family, member 1
Species Mouse (Mus musculus)
Entrez Gene ID 22408
Transcript(s) for this gene NM_021279 (2371 bp), XM_006520890 (2952 bp)
Official symbol Wnt4 [Mouse]
Official name wingless-type MMTV integration site family, member 4
Species Mouse (Mus musculus)
Entrez Gene ID 22417
Transcript(s) for this gene NM_009523 (3823 bp)
Official symbol Lrp2 [Mouse]
Official name low density lipoprotein receptor-related protein 2
Species Mouse (Mus musculus)
Entrez Gene ID 14725
Transcript(s) for this gene NM_001081088 (15467 bp), XM_130308 (15467 bp), XM_130363 (4408 bp), XM_899846 (4408 bp), XM_899854 (3986 bp), XM_899859 (15446 bp), XM_909085 (15467 bp), XM_921143 (2266 bp), XM_921164 (3986 bp), XM_921174 (15446 bp), XM_992598 (15482 bp), ENSMUST00000128742
Official symbol Wnt3a [Mouse]
Official name wingless-type MMTV integration site family, member 3A
Species Mouse (Mus musculus)
Entrez Gene ID 22416
Transcript(s) for this gene NM_009522 (2791 bp)
Official symbol Npc1 [Mouse]
Official name Niemann-Pick type C1
Species Mouse (Mus musculus)
Entrez Gene ID 18145
Transcript(s) for this gene NM_008720 (5209 bp), ENSMUST00000149211, XM_006525717 (5254 bp)
Official symbol Csnk1a1 [Mouse]
Official name casein kinase 1, alpha 1
Species Mouse (Mus musculus)
Entrez Gene ID 93687
Transcript(s) for this gene NM_146087 (2013 bp), ENSMUST00000170482, XM_006526383 (2262 bp), XM_006526384 (4548 bp), XM_006526385 (1663 bp), XM_006526386 (2226 bp), XM_006526387 (4512 bp), XM_006526388 (4464 bp), XM_011247048 (4248 bp), XR_386022 (0 bp), XR_386023 (0 bp)
Official symbol Prkaca [Mouse]
Official name protein kinase, cAMP dependent, catalytic, alpha
Species Mouse (Mus musculus)
Entrez Gene ID 18747
Transcript(s) for this gene NM_008854 (2300 bp), NM_001277898 (2257 bp)
Official symbol Smo [Mouse]
Official name smoothened, frizzled class receptor
Species Mouse (Mus musculus)
Entrez Gene ID 319757
Transcript(s) for this gene NM_176996 (3977 bp), XM_006505106 (3221 bp)
Official symbol Prkacb [Mouse]
Official name protein kinase, cAMP dependent, catalytic, beta
Species Mouse (Mus musculus)
Entrez Gene ID 18749
Transcript(s) for this gene NM_001164198 (4337 bp), NM_001164199 (4210 bp), NM_001164200 (4302 bp), NM_011100 (4341 bp), ENSMUST00000144369
Official symbol Csnk1e [Mouse]
Official name casein kinase 1, epsilon
Species Mouse (Mus musculus)
Entrez Gene ID 27373
Transcript(s) for this gene NM_013767 (2760 bp), ENSMUST00000156513, NM_001289898 (2756 bp), NM_001289899 (3174 bp), XM_006521037 (1527 bp), XM_006521038 (3033 bp), XM_006521039 (1488 bp), XM_006521040 (1452 bp), XM_006521041 (1417 bp), XM_006521042 (1899 bp), XM_006521043 (4327 bp), XM_006521044 (4266 bp), XM_006521046 (4217 bp), XM_011245649 (2814 bp), XM_011245650 (4323 bp), XM_011245651 (2779 bp), XM_011245652 (2743 bp), XM_011245653 (2734 bp), XM_011245654 (3189 bp), XM_011245655 (2734 bp)
Official symbol Gas1 [Mouse]
Official name growth arrest specific 1
Species Mouse (Mus musculus)
Entrez Gene ID 14451
Transcript(s) for this gene NM_008086 (3149 bp)
Official symbol Wnt2b [Mouse]
Official name wingless-type MMTV integration site family, member 2B
Species Mouse (Mus musculus)
Entrez Gene ID 22414
Transcript(s) for this gene NM_009520 (3573 bp)
Official symbol Siah1a [Mouse]
Official name seven in absentia 1A
Species Mouse (Mus musculus)
Entrez Gene ID 20437
Transcript(s) for this gene NM_009172 (2121 bp), XM_006530784 (1945 bp), XM_006530785 (2317 bp)
Official symbol Fbxw11 [Mouse]
Official name F-box and WD-40 domain protein 11
Species Mouse (Mus musculus)
Entrez Gene ID 103583
Transcript(s) for this gene NM_001271347 (4276 bp), NM_001271348 (4237 bp), NM_001271349 (4174 bp), NM_134015 (4339 bp), ENSMUST00000137898, XM_006514433 (5021 bp), XM_006514434 (4126 bp), XM_006514435 (4958 bp), XM_006514436 (4070 bp)
Official symbol Bmp5 [Mouse]
Official name bone morphogenetic protein 5
Species Mouse (Mus musculus)
Entrez Gene ID 12160
Transcript(s) for this gene NM_007555 (2528 bp), ENSMUST00000137213
Official symbol Cdon [Mouse]
Official name cell adhesion molecule-related/down-regulated by oncogenes
Species Mouse (Mus musculus)
Entrez Gene ID 57810
Transcript(s) for this gene NM_021339 (7236 bp), XM_006510507 (7246 bp), XM_006510508 (7415 bp), XM_006510509 (8150 bp), XM_006510510 (7475 bp), XM_006510511 (7246 bp), XM_006510512 (4445 bp), XM_006510513 (2425 bp), XM_006510514 (3768 bp)
Official symbol Gsk3b [Mouse]
Official name glycogen synthase kinase 3 beta
Species Mouse (Mus musculus)
Entrez Gene ID 56637
Transcript(s) for this gene NM_019827 (8298 bp), ENSMUST00000134870, XM_006522425 (6916 bp), XM_006522426 (6904 bp)
Official symbol Csnk1g1 [Mouse]
Official name casein kinase 1, gamma 1
Species Mouse (Mus musculus)
Entrez Gene ID 214897
Transcript(s) for this gene NM_173185 (7183 bp), ENSMUST00000153391, XM_006511008 (7207 bp), XM_006511009 (6889 bp), XM_006511010 (6727 bp), XM_006511011 (1264 bp), XM_006511012 (1880 bp), XM_011242703 (7321 bp), XM_011242704 (7439 bp), XM_011242705 (7256 bp), XM_011242706 (7374 bp), XM_011242707 (7272 bp), XM_011242708 (7297 bp), XM_011242709 (7210 bp), XM_011242710 (7186 bp), XM_011242711 (4774 bp), XM_011242712 (2339 bp)
Official symbol Kctd11 [Mouse]
Official name potassium channel tetramerisation domain containing 11
Species Mouse (Mus musculus)
Entrez Gene ID 216858
Transcript(s) for this gene NM_153143 (2740 bp)
Official symbol Ptchd3 [Mouse]
Official name patched domain containing 3
Species Mouse (Mus musculus)
Entrez Gene ID 74675
Transcript(s) for this gene NM_029049 (3238 bp), XM_001000283 (2403 bp), XM_109751 (2777 bp), XM_912872 (2777 bp), ENSMUST00000125199, XM_006534383 (1487 bp), XM_006534384 (2168 bp)
Official symbol Ptchd1 [Mouse]
Official name patched domain containing 1
Species Mouse (Mus musculus)
Entrez Gene ID 211612
Transcript(s) for this gene NM_001093750 (6489 bp), XM_142262 (2684 bp), XM_898890 (1918 bp), XM_898901 (636 bp), XM_911319 (2760 bp), XM_983712 (2684 bp), ENSMUST00000141356, XM_006528793 (3603 bp), XM_006528794 (3644 bp)
Official symbol 3110082D06Rik [Mouse]
Official name RIKEN cDNA 3110082D06 gene
Species Mouse (Mus musculus)
Entrez Gene ID 73235
Transcript(s) for this gene XM_140020 (999 bp), XM_910178 (6489 bp)