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RNAlater RNA Stabilization Reagent

Animal tissue에있는 RNA를 안정화 시킬 수 있습니다
  • 즉각적인 RNA stabilization과 protection이 신뢰할 수 있는 gene expression과 gene-profiling data를 만들어 냄
  • 편리하고 안전하게 실온에서 다룰 수 있음: 드라이아이스 또는 액체질소가 필요하지 않음
  • 얼림과 해동의 반복으로 인한 RNA degradation없이 조직 샘플을 장기 보관함
  • No need for liquid nitrogen or dry ice
  • Tissue archiving without risk of RNA degradation
RNAlater RNA Stabilization Reagent immediately stabilizes RNA in tissue samples to preserve the gene expression profile, and is supplied in 50 ml or 250 ml bottles. For stabilization of DNA, RNA, and protein in tissue samples, Allprotect Tissue Reagent can be used.

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Cat No./ID: 76104
RNAprotect Tissue Reagent (50 ml)
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50 ml RNAprotect Tissue Reagent for stabilization of RNA in 25 x 200 mg tissue samples

Cat No./ID: 76106
RNAprotect Tissue Reagent (250 ml)
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250 ml RNAprotect Tissue Reagent for stabilization of RNA in 125 x 200 mg tissue samples

The RNAlater RNA Stabilization Reagent is intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.

QIAGEN’s former RNA Stabilization Reagent, was manufactured and offered under license from Ambion, Inc., the owner of the RNAlater® trade mark. Following the expiration of that license and corresponding patents, QIAGEN’s new product name for the identical formulation is RNAprotect Tissue Reagent.

Product Details

Stable RNA in tissues: different temperatures and freeze–thaw cycles.
Total RNA was isolated from tissue samples stored in RNAprotect Tissue Reagent. [A] Rat lung tissue was stored under the indicated conditions. RNA was analyzed on a formaldehyde agarose gel and northern blot (GAPDH-probed). [B] Stabilized mouse liver tissue was subjected to freeze–thaw cycles (-20°C/25°C). C: control tissues frozen in liquid nitrogen and stored at -80°C.
RNAprotect Reagent prevents degradation of mRNA in tissues.
RNA was isolated from fresh rat kidney samples after 0, 5, 10, 15, 30, and 60 minutes, using either standard procedures (Unstabilized) or RNeasy Protect Kits (Stabilized). The RNA isolated was analyzed by agarose gel electrophoresis and expression of GAPDH was examined using northern blot analysis. M: markers.
RNAlater Stabilization Reagent stabilizes and protects the RNA expression pattern of samples during harvest and storage (see figure "RNAlater Reagent prevents degradation of mRNA in tissues"). Immediate protection with RNAlater technology ensures that downstream analyses truly reflect the expression profile of the intact tissues (see figure "RNAlater TissueProtect Tubes prevent RNA changes in tissues"). Samples can be archived without risk of RNA degradation, even after multiple freeze–thaw cycles. RNeasy purified RNA from RNAlater stabilized samples stored under a wide variety of conditions is ideal for downstream processes such as northern blotting and RT-PCR (see figure "Stable RNA in tissues: different temperatures and freeze–thaw cycles").

Once a biological sample is harvested, its RNA becomes extremely unstable. The innovative, aqueous RNAlater RNA Stabilization Reagent quickly permeates tissues resulting in immediate stabilization of the RNA and preservation of the RNA expression pattern. Gene induction or down-regulation triggered by sample manipulation is also prevented, allowing accurate analysis of gene expression.


For RNA protection and sample storage, tissue samples are submerged in an appropriate volume of RNAlater RNA Stabilization Reagent immediately after harvesting. RNAlater TissueProtect Tubes provide premeasured volumes of RNAlater RNA Stabilization Reagent in reclosable tubes for convenient handling and sample storage. The reagent preserves RNA for up to 1 day at 37°C, 7 days at 18–25°C, or 4 weeks at 2–8°C, allowing processing, transportation, storage, and shipping of samples without liquid nitrogen or dry ice. Alternatively, the samples can also be placed at –20°C or –80°C for archival storage.


Animal and human tissues stabilized in RNAlater RNA Stabilization Reagent can be efficiently disrupted using QIAGEN instruments for sample disruption, and used with QIAGEN kits for:

  • Total RNA purification
  • miRNA purification
  • mRNA purification

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Kit Handbooks (1)
RNAprotect Tissue Tubes - For collection of harvested animal tissues with immediate stabilization of the gene expression profile, and subsequent transport and storage; RNAprotect Tissue Reagent - For immediate stabilization of the gene expression profile in harvested animal tissues
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