COSMIC

Catalogue of Somatic Mutations in Cancer

Features

  • Cited more than 10,000 times
  • Curated knowledge from more than 27,000 peer reviewed publications
  • Genome wide screen data from more than 37,000 genomes
  • More than 37 million somatic mutations
  • Cancer Gene Census

Products

The COSMIC is intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
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COSMIC

Cat. No. / ID: 834332

License for non-profit organizations who engage in patient testing or for commercial organizations. Access, download, and mine COSMIC's core data consisting of over 1.4 M cancer samples and over 38M somatic coding mutations. In addition, download and mine focused projects such as the Cancer Mutation Census and Actionability.

Product Details

COSMIC is the gold standard database for somatic mutation information.

Performance

COSMIC, the Catalogue Of Somatic Mutations In Cancer is the most detailed and comprehensive resource for exploring the effect of somatic mutations in human cancer. In addition to coding mutations, COSMIC covers all the genetic mechanisms by which somatic mutations promote cancer, including non-coding mutations, gene fusions, copy-number variants and drug-resistance mutations. It includes the Cancer Gene Census (CGC), an expert-curated library of cancer-driving genes in humans, and a standard in cancer genetics across basic research, medical reporting and pharmaceutical development.

Principle

COSMIC data are carefully selected, collected and standardized through manual curation by scientific experts, ensuring high quality, accuracy and descriptive data capture.

Procedure

COSMIC data is available as a download, ready for you to integrate into your current pipelines and tools. You also will get access to any updates released during the one-year subscription period, as well as access to our support team.

Applications

Discover potential drug targets and biomarkers for cancer. Improve cohort selection for clinical trials. Identify driver mutations and relevant genes to support patient diagnosis.

Publications

COSMIC: the Catalogue Of Somatic Mutations In Cancer.
Tate JG; Bamford S; Jubb HC; Sondka Z; Beare DM; Bindal N; Boutselakis H; Cole CG; Creatore C; Dawson E; Fish P; Harsha B; Hathaway C; Jupe SC; Kok CY; Noble K; Ponting L; Ramshaw CC; Rye CE; Speedy HE; Stefancsik R; Thompson SL; Wang S; Ward S; Campbell PJ; Forbes SA;
Nucleic Acids Res; 2019; 47 (D1):D941-D947 2019 Jan 8 PMID:30371878
The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers.
Sondka Z; Bamford S; Cole CG; Ward SA; Dunham I; Forbes SA;
Nat Rev Cancer; 2018; 18 (11):696-705 2018 Nov PMID:30293088